DCK
deoxycytidine kinase
Summary
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Known Variants10 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3775289 | 4:71,862,674 | T/C | intron variant | — |
| rs1196177921 | 4:71,863,808 | A/G | — | uncertain significance |
| rs180909161 | 4:71,879,974 | A/G | intron variant | — |
| rs111454937 | 4:71,888,235 | A/G | missense variant | — |
| rs1578429814 | 4:71,889,300 | T/C | — | likely benign |
| rs777492188 | 4:71,889,334 | A/G | — | uncertain significance |
| rs4694362 | 4:71,893,864 | C/T | intron variant | — |
| rs12513202 | 4:71,894,563 | C/G | — | — |
| rs72552079 | 4:71,895,668 | T/C | 3 prime UTR variant | — |
| rs1803484 | 4:71,896,343 | A/G | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.