DCLRE1B

DNA cross-link repair 1B

Summary

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]

Known Variants126 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs189306022	1:114,447,611	T/C	—	benign
rs971173	1:114,447,914	G/T	—	benign
rs28381068	1:114,448,197	A/G	—	benign
rs1437958560	1:114,448,218	G/A	—	uncertain significance
rs34713392	1:114,448,220	C/T	—	likely benign
rs746144334	1:114,448,223	G/C	—	likely benign
rs1333588223	1:114,448,249	A/G	—	uncertain significance
rs142343310	1:114,448,269	G/C	—	uncertain significance
rs1668880591	1:114,448,281	C/A	—	uncertain significance
rs1553260999	1:114,448,285	T/G	—	uncertain significance
rs747335906	1:114,448,307	C/T	—	likely benign
rs757534089	1:114,448,319	C/A	—	likely benign
rs200788189	1:114,448,342	C/T	—	uncertain significance
rs768672121	1:114,448,343	C/T	—	likely benign
rs774397708	1:114,448,344	C/T	—	uncertain significance
rs28381069	1:114,448,345	G/T	—	uncertain significance
rs760179150	1:114,448,361	C/G	—	likely benign
rs764770290	1:114,448,386	C/G	—	uncertain significance
rs1668897682	1:114,448,396	A/C	—	uncertain significance
rs1242019671	1:114,449,615	C/G	—	uncertain significance
rs770692934	1:114,449,646	A/C	—	uncertain significance
rs776471212	1:114,449,654	G/C	—	uncertain significance
rs3761936	1:114,449,662	T/C	—	benign
rs762552451	1:114,449,671	C/G	—	likely benign
rs369471152	1:114,449,675	G/A	—	uncertain significance
rs773744466	1:114,449,676	A/G	—	pathogenic
rs761321321	1:114,449,681	A/G	—	uncertain significance
rs1439653012	1:114,449,688	A/G	—	uncertain significance
rs199758910	1:114,449,701	C/T	—	likely benign
rs755192360	1:114,449,702	G/A	—	uncertain significance
rs144640614	1:114,449,707	C/T	—	likely benign
rs758475213	1:114,449,708	C/T	—	uncertain significance
rs2101068175	1:114,449,769	C/G	—	uncertain significance
rs11102701	1:114,449,829	T/A	—	benign
rs768197482	1:114,449,835	T/A	—	benign
rs55868414	1:114,449,856	T/A	—	benign
rs1200456480	1:114,449,857	A/T	—	benign
rs893050696	1:114,449,858	A/T	—	benign
rs1159463066	1:114,449,862	A/T	—	benign
rs114661042	1:114,450,022	G/A	—	benign
rs201626532	1:114,450,639	C/T	—	pathogenic
rs1339289910	1:114,450,652	C/T	—	uncertain significance
rs140411676	1:114,450,669	G/C	—	uncertain significance
rs375188357	1:114,450,670	C/T	—	uncertain significance
rs763252884	1:114,450,700	T/C	—	pathogenic
rs769100574	1:114,450,701	A/T	—	pathogenic
rs774530909	1:114,450,705	C/T	—	likely benign
rs369389853	1:114,450,722	C/G	—	uncertain significance
rs150374247	1:114,450,747	C/T	—	uncertain significance
rs752337831	1:114,450,748	G/A	—	likely benign
rs138603501	1:114,450,783	C/T	—	uncertain significance
rs774706467	1:114,450,784	G/A	—	uncertain significance
rs1669111834	1:114,450,794	A/G	—	likely benign
rs375674908	1:114,450,799	A/G	—	uncertain significance
rs144459176	1:114,450,803	C/T	—	likely benign
rs11102702	1:114,450,964	T/C	—	benign
rs1421095735	1:114,453,796	C/T	—	likely benign
rs1401066315	1:114,453,831	G/A	—	uncertain significance
rs2101074559	1:114,453,860	C/T	—	likely benign
rs755456896	1:114,453,903	A/G	—	uncertain significance
rs1303681560	1:114,453,908	G/A	—	uncertain significance
rs961147040	1:114,453,917	A/G	—	uncertain significance
rs200330629	1:114,453,946	T/C	—	likely benign
rs745991382	1:114,453,966	C/T	—	uncertain significance
rs574323645	1:114,453,967	G/C	—	likely benign
rs775524261	1:114,453,974	A/G	—	uncertain significance
rs768273057	1:114,453,985	A/G	—	likely benign
rs1478635543	1:114,453,995	A/G	—	uncertain significance
rs201357602	1:114,454,021	C/T	—	pathogenic
rs946912356	1:114,454,047	C/T	—	uncertain significance
rs532282272	1:114,454,054	C/G	—	likely benign
rs145569979	1:114,454,061	C/T	—	likely benign
rs143568469	1:114,454,062	G/A	—	uncertain significance
rs773997509	1:114,454,072	C/T	—	likely benign
rs772803140	1:114,454,093	G/C	—	uncertain significance
rs921843370	1:114,454,106	G/A	—	uncertain significance
rs1216262296	1:114,454,113	G/A	—	uncertain significance
rs1199130382	1:114,454,137	A/G	—	uncertain significance
rs201436658	1:114,454,143	T/A	—	uncertain significance
rs368157267	1:114,454,158	C/G	—	uncertain significance
rs749431578	1:114,454,160	G/A	—	conflicting classifications of pathogenicity
rs754841219	1:114,454,164	C/G	—	uncertain significance
rs771842799	1:114,454,174	G/A	—	likely benign
rs370614998	1:114,454,175	G/A	—	uncertain significance
rs759123178	1:114,454,191	A/T	—	uncertain significance
rs750879802	1:114,454,207	T/C	—	likely benign
rs200392246	1:114,454,218	G/A	—	uncertain significance
rs527254164	1:114,454,254	C/T	—	uncertain significance
rs777529403	1:114,454,272	T/C	—	uncertain significance
rs2526745411	1:114,454,284	C/T	—	likely benign
rs780781288	1:114,454,307	C/G	—	uncertain significance
rs183344879	1:114,454,351	T/A	—	likely benign
rs142747676	1:114,454,362	C/T	—	uncertain significance
rs759682384	1:114,454,363	G/A	—	likely benign
rs745340882	1:114,454,377	A/G	—	uncertain significance
rs539008433	1:114,454,391	C/T	—	uncertain significance
rs758926583	1:114,454,395	T/G	—	uncertain significance
rs141081316	1:114,454,397	C/T	—	uncertain significance
rs146482651	1:114,454,398	G/A	—	conflicting classifications of pathogenicity
rs769393520	1:114,454,402	C/G	—	uncertain significance

Showing 100 of 126 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.