DCN

decorin

Summary

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Known Variants67 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7319863212:91,534,810C/Tregulatory region variant—
rs144926317512:91,539,269A/T—uncertain significance
rs88604988812:91,539,392A/C—uncertain significance
rs3537981212:91,539,458A/G—benign
rs77880555812:91,539,481T/C—uncertain significance
rs120145881212:91,539,484A/G—uncertain significance
rs188096754412:91,539,494T/C—uncertain significance
rs88604988912:91,539,546T/A—uncertain significance
rs88604989012:91,539,615C/G—uncertain significance
rs744112:91,539,675G/A—benign
rs56409165712:91,539,687A/C—uncertain significance
rs19143477812:91,539,730C/T—benign
rs53154157012:91,539,755G/A—uncertain significance
rs180334312:91,539,784T/C—benign
rs77566628312:91,539,849C/T—conflicting classifications of pathogenicity
rs76523918512:91,539,853T/A—uncertain significance
rs75825104112:91,539,865G/T—likely benign
rs75110241612:91,539,867G/A—uncertain significance
rs20019195512:91,539,870C/T—uncertain significance
rs249922823512:91,539,879A/C—not provided
rs188099285512:91,539,882T/C—uncertain significance
rs249922841012:91,539,901C/G—uncertain significance
rs8012367812:91,539,940C/T—benign
rs53612775712:91,539,956T/C—uncertain significance
rs77727060812:91,539,971G/T—likely benign
rs249922914212:91,539,974G/A—uncertain significance
rs7335805512:91,539,998A/G—benign
rs313827612:91,543,668A/Gintron variant—
rs14430789112:91,545,437G/A—likely benign
rs249925355612:91,545,438T/C—uncertain significance
rs53344875412:91,545,460C/T—uncertain significance
rs313826812:91,545,513G/A—benign
rs249925430712:91,545,518G/C—likely benign
rs313826412:91,546,916T/G—benign
rs142863491412:91,546,922T/C—uncertain significance
rs14417442612:91,546,948G/A—conflicting classifications of pathogenicity
rs76015213612:91,546,961G/A—uncertain significance
rs20174060912:91,550,866G/A—uncertain significance
rs75851060712:91,550,872T/C—uncertain significance
rs37367621712:91,550,883A/C—conflicting classifications of pathogenicity
rs55570583012:91,550,944T/C—uncertain significance
rs14776504312:91,550,949C/A—likely benign
rs13905707312:91,550,950G/A—uncertain significance
rs20143026112:91,552,082T/A—benign
rs188193966912:91,552,174T/C—uncertain significance
rs14275240112:91,552,187T/C—benign
rs51611512:91,557,292T/G——
rs313822112:91,558,424G/A—benign
rs249930640312:91,558,473T/A—uncertain significance
rs19121824912:91,558,500A/G—benign
rs20051635512:91,572,120C/T—uncertain significance
rs135651093912:91,572,188G/T—uncertain significance
rs96262562912:91,572,200G/C—uncertain significance
rs188342825712:91,572,203C/T—uncertain significance
rs188343369812:91,572,238T/C—uncertain significance
rs14559744112:91,572,276C/T—likely benign
rs14173816812:91,572,297T/C—benign
rs101105752712:91,572,320T/C—uncertain significance
rs313816712:91,572,415C/Tintron variant—
rs313816512:91,572,734G/Aregulatory region variant—
rs1331281612:91,575,207T/Aintron variant—
rs75717890612:91,576,578T/A—uncertain significance
rs55153480912:91,576,585T/C—uncertain significance
rs18985335812:91,576,647T/C—likely benign
rs54001321812:91,576,694G/A—likely benign
rs88604989112:91,576,705T/C—uncertain significance
rs14795686912:91,576,723T/C—likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.