DCP1A
decapping mRNA 1A
Summary
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs78996616 | 3:53,321,619 | G/T | — | uncertain significance |
| rs2471248481 | 3:53,322,178 | A/G | — | uncertain significance |
| rs781910772 | 3:53,326,107 | G/A | — | uncertain significance |
| rs143190624 | 3:53,326,142 | G/A | — | benign |
| rs371233245 | 3:53,326,205 | C/T | — | uncertain significance |
| rs375539952 | 3:53,326,271 | T/C | — | uncertain significance |
| rs2471259359 | 3:53,326,325 | C/G | — | uncertain significance |
| rs1158506776 | 3:53,326,389 | G/A | — | uncertain significance |
| rs201480018 | 3:53,326,419 | G/A | — | uncertain significance |
| rs369794168 | 3:53,326,442 | G/C | — | uncertain significance |
| rs199632820 | 3:53,326,467 | T/C | — | uncertain significance |
| rs782753531 | 3:53,326,490 | A/T | — | uncertain significance |
| rs781827654 | 3:53,326,494 | G/T | — | uncertain significance |
| rs781900316 | 3:53,326,625 | G/C | — | uncertain significance |
| rs374845014 | 3:53,326,689 | A/T | — | uncertain significance |
| rs62256059 | 3:53,330,051 | C/T | intron variant | — |
| rs79648456 | 3:53,335,720 | C/T | intron variant | — |
| rs376112114 | 3:53,338,223 | G/A | — | uncertain significance |
| rs1350541363 | 3:53,346,366 | C/T | — | uncertain significance |
| rs375482000 | 3:53,346,389 | C/T | — | uncertain significance |
| rs782331318 | 3:53,346,407 | A/G | — | uncertain significance |
| rs561746114 | 3:53,360,918 | T/C | — | — |
| rs782232723 | 3:53,376,290 | G/T | — | uncertain significance |
| rs2029213 | 3:53,378,245 | C/G | — | — |
| rs2471353685 | 3:53,378,953 | T/A | — | uncertain significance |
| rs781953979 | 3:53,381,480 | T/C | — | uncertain significance |
| rs1553693321 | 3:53,381,525 | G/C | — | uncertain significance |
| rs555794342 | 3:53,381,537 | G/A | — | uncertain significance |
| rs141367465 | 3:53,381,546 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.