DDOST

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Summary

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Known Variants214 total

rsidPosition (GRCh37)AllelesClassClinVar
rs10575237081:20,978,855G/A—likely benign
rs20533024301:20,978,862C/T—likely benign
rs7644068901:20,978,878G/A—likely benign
rs3702267251:20,978,887C/T—likely benign
rs1176348381:20,978,899G/A—likely benign
rs7603908811:20,978,905G/T—uncertain significance
rs9232350611:20,978,911G/A—likely benign
rs3740320541:20,978,918A/T—not provided
rs25452722021:20,978,929C/G—likely benign
rs7813129021:20,978,949C/T—uncertain significance
rs9319153081:20,978,950G/A—likely benign
rs3768943171:20,978,956G/A—likely benign
rs7498230191:20,978,966T/C—uncertain significance
rs1424411241:20,978,971C/T—likely benign
rs7462728031:20,978,972G/A—uncertain significance
rs3690252941:20,978,974G/A—likely benign
rs7761718311:20,978,976G/A—uncertain significance
rs7691928871:20,978,982A/G—uncertain significance
rs1488839981:20,978,983G/A—likely benign
rs12629653701:20,978,986C/T—likely benign
rs5309907531:20,978,996G/A—uncertain significance
rs3733293101:20,979,011C/T—uncertain significance
rs2006362461:20,979,015C/T—uncertain significance
rs1495760511:20,979,016G/A—benign
rs7540363211:20,979,021C/T—uncertain significance
rs20533062331:20,979,030G/C—likely benign
rs11861442201:20,979,126G/A—likely benign
rs25452727451:20,979,133T/C—uncertain significance
rs1459400091:20,979,136G/A—conflicting classifications of pathogenicity
rs745267041:20,979,148C/T—uncertain significance
rs1385619241:20,979,149G/A—uncertain significance
rs7774557861:20,979,186G/A—likely benign
rs8860458641:20,979,188C/T—uncertain significance
rs10042995141:20,979,207A/G—likely benign
rs15704123701:20,979,222T/G—uncertain significance
rs2018756791:20,979,225G/A—likely benign
rs7518530151:20,979,324C/T—likely benign
rs7553968871:20,979,325G/A—likely benign
rs20533122341:20,979,379A/G—uncertain significance
rs7769361811:20,979,382C/T—uncertain significance
rs7621148381:20,979,383G/A—uncertain significance
rs1907806041:20,979,408G/A—likely benign
rs9212101471:20,979,452C/T—uncertain significance
rs2002478421:20,979,459A/G—likely benign
rs7568707251:20,979,471T/G—likely benign
rs361105751:20,979,573C/T—benign
rs124101931:20,979,580T/G—benign
rs6225251:20,979,818A/Tupstream gene variantbenign
rs25452742661:20,980,105C/G—likely benign
rs7647557421:20,980,145T/C—uncertain significance
rs25452743351:20,980,147G/T—likely benign
rs13933641421:20,980,154G/A—uncertain significance
rs178496341:20,980,162G/A—uncertain significance
rs25452743631:20,980,165C/T—uncertain significance
rs1453277081:20,980,168C/G—likely benign
rs1179256991:20,980,169C/T—benign
rs7744560701:20,980,178G/A—uncertain significance
rs3678074791:20,980,193C/A—uncertain significance
rs3717517241:20,980,194G/A—uncertain significance
rs7545613841:20,980,223C/T—uncertain significance
rs7675257411:20,980,224G/A—uncertain significance
rs25452745131:20,980,236C/T—uncertain significance
rs3691055901:20,980,247T/C—uncertain significance
rs2019624571:20,980,267C/T—conflicting classifications of pathogenicity
rs7621348041:20,980,270G/C—uncertain significance
rs20706601:20,980,450G/T—benign
rs1426134841:20,980,680C/T—likely benign
rs11567325481:20,980,706T/C—likely benign
rs10052462351:20,980,726C/T—uncertain significance
rs21545342351:20,980,728G/A—uncertain significance
rs9613893841:20,980,730C/T—likely benign
rs7570335271:20,980,733C/T—likely benign
rs1380611341:20,980,734G/A—likely benign
rs12183154211:20,980,757G/A—likely benign
rs1997822791:20,980,758A/G—uncertain significance
rs12530590461:20,980,766G/A—likely benign
rs7801039811:20,980,777C/T—uncertain significance
rs1491149701:20,980,778G/T—likely benign
rs20533398011:20,980,782G/A—uncertain significance
rs1505519931:20,980,798C/T—uncertain significance
rs341890971:20,980,799G/A—likely benign
rs7740943001:20,980,800C/T—uncertain significance
rs7488041451:20,980,801G/A—uncertain significance
rs12442677971:20,980,816C/A—uncertain significance
rs413077751:20,980,847C/T—benign
rs7650030101:20,980,854G/A—uncertain significance
rs25452753591:20,980,857T/A—uncertain significance
rs5434070201:20,980,878G/A—likely benign
rs6072541:20,980,880G/A—benign
rs20706581:20,980,922G/A—benign
rs1395721181:20,980,988G/A—likely benign
rs7680629191:20,981,088A/G—likely benign
rs3742297901:20,981,098A/G—likely benign
rs8670454201:20,981,107C/G—pathogenic
rs12804494451:20,981,111G/A—uncertain significance
rs7651992871:20,981,117G/A—uncertain significance
rs9617918071:20,981,120T/A—uncertain significance
rs7729700101:20,981,125C/T—uncertain significance
rs1446566151:20,981,126G/A—uncertain significance
rs9271192371:20,981,127G/A—uncertain significance

Showing 100 of 214 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.