DERL3

derlin 3

Summary

The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Known Variants13 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37576919822:24,179,263G/Cuncertain significance
rs36900403422:24,179,303C/Tuncertain significance
rs11784667822:24,179,334C/Tlikely benign
rs37275592022:24,179,892C/Tuncertain significance
rs14765217222:24,179,944T/Cuncertain significance
rs14223145922:24,179,990T/Cuncertain significance
rs75062112422:24,180,550C/Auncertain significance
rs75896300922:24,180,758G/Cuncertain significance
rs37549131222:24,180,772A/Cuncertain significance
rs36882515722:24,180,775C/Auncertain significance
rs74774782122:24,180,778A/Cuncertain significance
rs77774436622:24,180,797A/Cuncertain significance
rs54361342222:24,182,239A/G

Gene information from NCBI Gene. Variant classifications from ClinVar.