DET1
DET1 partner of COP1 E3 ubiquitin ligase
Summary
Enables ubiquitin protein ligase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs202049856 | 15:89,056,201 | A/T | — | uncertain significance |
| rs2056234947 | 15:89,056,260 | A/T | — | uncertain significance |
| rs17190166 | 15:89,056,502 | C/A | regulatory region variant | — |
| rs375810992 | 15:89,060,107 | C/T | — | uncertain significance |
| rs201452172 | 15:89,060,204 | C/T | — | likely benign |
| rs200079182 | 15:89,070,854 | T/A | — | uncertain significance |
| rs2505344672 | 15:89,070,880 | C/T | — | likely benign |
| rs1259868435 | 15:89,070,937 | C/G | — | uncertain significance |
| rs1248569680 | 15:89,070,951 | C/G | — | uncertain significance |
| rs778315040 | 15:89,070,985 | C/T | — | likely benign |
| rs201960185 | 15:89,070,986 | G/A | — | uncertain significance |
| rs2142299011 | 15:89,070,993 | T/G | — | uncertain significance |
| rs769807161 | 15:89,071,001 | A/G | — | uncertain significance |
| rs1361900850 | 15:89,073,924 | T/A | — | uncertain significance |
| rs781251361 | 15:89,074,024 | G/A | — | uncertain significance |
| rs1432973932 | 15:89,074,040 | C/A | — | uncertain significance |
| rs754018534 | 15:89,074,101 | C/G | — | uncertain significance |
| rs771658609 | 15:89,074,176 | C/T | — | uncertain significance |
| rs1296916526 | 15:89,074,241 | C/G | — | uncertain significance |
| rs2505359433 | 15:89,074,290 | A/G | — | uncertain significance |
| rs1419982279 | 15:89,074,312 | A/C | — | uncertain significance |
| rs200801177 | 15:89,074,337 | G/A | — | likely benign |
| rs370446446 | 15:89,074,386 | G/T | — | uncertain significance |
| rs199812495 | 15:89,074,413 | C/T | — | uncertain significance |
| rs1307210181 | 15:89,074,459 | C/G | — | uncertain significance |
| rs749778687 | 15:89,074,570 | G/A | — | uncertain significance |
| rs371895445 | 15:89,074,578 | A/G | — | uncertain significance |
| rs755327536 | 15:89,074,581 | C/T | — | uncertain significance |
| rs547746422 | 15:89,074,582 | G/A | — | uncertain significance |
| rs374698448 | 15:89,074,587 | C/T | — | uncertain significance |
| rs189659683 | 15:89,074,605 | T/A | — | uncertain significance |
| rs374827494 | 15:89,074,863 | C/T | — | uncertain significance |
| rs757677557 | 15:89,074,866 | C/T | — | uncertain significance |
| rs367738496 | 15:89,074,867 | G/A | — | uncertain significance |
| rs201071368 | 15:89,074,875 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.