DHX36

DEAH-box helicase 36

Summary

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs24730056033:153,993,967T/Cuncertain significance
rs1400107683:153,993,985C/Tuncertain significance
rs3728477143:153,994,001T/Cuncertain significance
rs3772130393:153,994,079T/Cuncertain significance
rs15768521793:153,994,105A/Guncertain significance
rs12079284643:153,994,628T/Auncertain significance
rs12035341303:153,994,651C/Guncertain significance
rs3724651143:153,995,424T/Cuncertain significance
rs7629310173:153,998,432T/Cuncertain significance
rs14872473813:154,001,024C/Tuncertain significance
rs24730152793:154,001,036C/Guncertain significance
rs7558293563:154,001,039G/Auncertain significance
rs24730172743:154,002,386C/Tuncertain significance
rs7595902283:154,002,437C/Auncertain significance
rs9086383663:154,006,710A/Guncertain significance
rs7753552063:154,007,553T/Cuncertain significance
rs7479912253:154,010,404T/Cuncertain significance
rs24730336013:154,013,074T/Auncertain significance
rs2019950493:154,013,090T/Cuncertain significance
rs24730396353:154,017,689G/Auncertain significance
rs13449893563:154,017,693G/Cuncertain significance
rs7707402393:154,018,397C/Tuncertain significance
rs7743930873:154,018,405C/Tuncertain significance
rs2014005343:154,018,451T/Cuncertain significance
rs24730407753:154,018,468A/Guncertain significance
rs7509709563:154,018,477G/Auncertain significance
rs2011755803:154,018,849T/Cuncertain significance
rs7810317683:154,021,194A/Guncertain significance
rs133190673:154,022,441T/Cintron variant
rs3714916243:154,022,739T/Cuncertain significance
rs7783816313:154,024,084C/Guncertain significance
rs24730537043:154,027,555A/Tuncertain significance
rs7739831003:154,033,919C/Tuncertain significance
rs3557773:154,034,950G/Cintron variant
rs24730762073:154,041,995C/Tuncertain significance
rs3765578713:154,042,069C/Auncertain significance
rs2014130993:154,042,131C/Tlikely benign
rs7586110033:154,042,156C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.