DHX36
DEAH-box helicase 36
Summary
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2473005603 | 3:153,993,967 | T/C | — | uncertain significance |
| rs140010768 | 3:153,993,985 | C/T | — | uncertain significance |
| rs372847714 | 3:153,994,001 | T/C | — | uncertain significance |
| rs377213039 | 3:153,994,079 | T/C | — | uncertain significance |
| rs1576852179 | 3:153,994,105 | A/G | — | uncertain significance |
| rs1207928464 | 3:153,994,628 | T/A | — | uncertain significance |
| rs1203534130 | 3:153,994,651 | C/G | — | uncertain significance |
| rs372465114 | 3:153,995,424 | T/C | — | uncertain significance |
| rs762931017 | 3:153,998,432 | T/C | — | uncertain significance |
| rs1487247381 | 3:154,001,024 | C/T | — | uncertain significance |
| rs2473015279 | 3:154,001,036 | C/G | — | uncertain significance |
| rs755829356 | 3:154,001,039 | G/A | — | uncertain significance |
| rs2473017274 | 3:154,002,386 | C/T | — | uncertain significance |
| rs759590228 | 3:154,002,437 | C/A | — | uncertain significance |
| rs908638366 | 3:154,006,710 | A/G | — | uncertain significance |
| rs775355206 | 3:154,007,553 | T/C | — | uncertain significance |
| rs747991225 | 3:154,010,404 | T/C | — | uncertain significance |
| rs2473033601 | 3:154,013,074 | T/A | — | uncertain significance |
| rs201995049 | 3:154,013,090 | T/C | — | uncertain significance |
| rs2473039635 | 3:154,017,689 | G/A | — | uncertain significance |
| rs1344989356 | 3:154,017,693 | G/C | — | uncertain significance |
| rs770740239 | 3:154,018,397 | C/T | — | uncertain significance |
| rs774393087 | 3:154,018,405 | C/T | — | uncertain significance |
| rs201400534 | 3:154,018,451 | T/C | — | uncertain significance |
| rs2473040775 | 3:154,018,468 | A/G | — | uncertain significance |
| rs750970956 | 3:154,018,477 | G/A | — | uncertain significance |
| rs201175580 | 3:154,018,849 | T/C | — | uncertain significance |
| rs781031768 | 3:154,021,194 | A/G | — | uncertain significance |
| rs13319067 | 3:154,022,441 | T/C | intron variant | — |
| rs371491624 | 3:154,022,739 | T/C | — | uncertain significance |
| rs778381631 | 3:154,024,084 | C/G | — | uncertain significance |
| rs2473053704 | 3:154,027,555 | A/T | — | uncertain significance |
| rs773983100 | 3:154,033,919 | C/T | — | uncertain significance |
| rs355777 | 3:154,034,950 | G/C | intron variant | — |
| rs2473076207 | 3:154,041,995 | C/T | — | uncertain significance |
| rs376557871 | 3:154,042,069 | C/A | — | uncertain significance |
| rs201413099 | 3:154,042,131 | C/T | — | likely benign |
| rs758611003 | 3:154,042,156 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.