DHX8

DEAH-box helicase 8

Summary

This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Known Variants36 total

rsidPosition (GRCh37)AllelesClassClinVar
rs77236672217:41,561,409G/Tuncertain significance
rs75964492917:41,561,431G/Tuncertain significance
rs75289478717:41,561,433G/Tuncertain significance
rs14973191017:41,561,460G/Auncertain significance
rs20132512917:41,561,545A/Guncertain significance
rs215458631217:41,566,829T/Cuncertain significance
rs19257622217:41,566,879G/Auncertain significance
rs254390716217:41,567,810G/Auncertain significance
rs196849632917:41,568,547C/Tuncertain significance
rs140174007417:41,570,057C/Tuncertain significance
rs135902343917:41,570,068A/Cuncertain significance
rs19197765017:41,570,071C/Tuncertain significance
rs14331676317:41,570,078G/Auncertain significance
rs117088931417:41,570,104G/Cuncertain significance
rs74547726517:41,570,126G/Auncertain significance
rs77249049917:41,570,138A/Tuncertain significance
rs76588487417:41,570,279A/Tuncertain significance
rs196862849917:41,570,348A/Guncertain significance
rs20063994517:41,570,404C/Guncertain significance
rs75495269317:41,570,857A/Cuncertain significance
rs76575664817:41,571,105G/Auncertain significance
rs98725955217:41,582,057T/Cuncertain significance
rs135629305017:41,582,105A/Tuncertain significance
rs20110319917:41,584,374G/Auncertain significance
rs77121434517:41,585,002C/Tlikely benign
rs94856550017:41,585,256A/Guncertain significance
rs254400983017:41,585,730G/Auncertain significance
rs19962688417:41,597,494C/Alikely benign
rs144309998617:41,597,633C/Tuncertain significance
rs3562063517:41,598,230G/Auncertain significance
rs215458689817:41,598,737G/Auncertain significance
rs98930480817:41,598,893G/Tuncertain significance
rs143152913117:41,599,470A/Guncertain significance
rs5719081217:41,600,986C/Tbenign
rs53055501017:41,644,826A/G
rs234313217:41,655,069T/Aintron variant

Gene information from NCBI Gene. Variant classifications from ClinVar.