DIS3L
DIS3 like exosome 3'-5' exoribonuclease
Summary
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
Known Variants78 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2092546107 | 15:66,585,939 | T/G | — | uncertain significance |
| rs895099218 | 15:66,585,942 | A/C | — | uncertain significance |
| rs1367517378 | 15:66,585,950 | G/C | — | uncertain significance |
| rs1003496349 | 15:66,586,001 | C/T | — | uncertain significance |
| rs1034934127 | 15:66,586,008 | A/G | — | uncertain significance |
| rs557876063 | 15:66,587,332 | A/G | — | uncertain significance |
| rs766157127 | 15:66,587,334 | C/G | — | uncertain significance |
| rs2544731758 | 15:66,587,452 | A/G | — | uncertain significance |
| rs72748330 | 15:66,589,955 | G/A | upstream gene variant | — |
| rs16949788 | 15:66,590,037 | T/C | upstream gene variant | — |
| rs35192697 | 15:66,590,448 | C/T | upstream gene variant | — |
| rs11854159 | 15:66,597,110 | G/T | intron variant | — |
| rs200836203 | 15:66,599,179 | G/A | — | uncertain significance |
| rs1484204064 | 15:66,599,284 | A/C | — | uncertain significance |
| rs149513595 | 15:66,601,052 | T/G | — | uncertain significance |
| rs373688806 | 15:66,601,157 | A/G | — | uncertain significance |
| rs2092763964 | 15:66,604,102 | A/T | — | uncertain significance |
| rs373895810 | 15:66,604,188 | C/G | — | uncertain significance |
| rs139490064 | 15:66,604,228 | G/T | — | uncertain significance |
| rs2544805006 | 15:66,606,390 | T/A | — | uncertain significance |
| rs767664381 | 15:66,607,399 | C/A | — | uncertain significance |
| rs748072849 | 15:66,607,511 | G/A | — | uncertain significance |
| rs8035939 | 15:66,609,740 | G/A | intron variant | — |
| rs141249657 | 15:66,610,789 | C/G | — | uncertain significance |
| rs2092843895 | 15:66,610,792 | G/T | — | uncertain significance |
| rs774217832 | 15:66,610,854 | G/C | — | uncertain significance |
| rs375710056 | 15:66,610,891 | G/A | — | uncertain significance |
| rs200353973 | 15:66,610,907 | A/G | — | uncertain significance |
| rs756223198 | 15:66,610,925 | G/A | — | uncertain significance |
| rs771942723 | 15:66,612,909 | G/A | — | uncertain significance |
| rs200344612 | 15:66,612,917 | G/C | — | uncertain significance |
| rs150139050 | 15:66,612,927 | C/T | — | uncertain significance |
| rs1429766478 | 15:66,612,931 | T/G | — | uncertain significance |
| rs371410266 | 15:66,612,936 | T/G | — | uncertain significance |
| rs773245840 | 15:66,612,978 | C/T | — | uncertain significance |
| rs139303382 | 15:66,613,009 | G/A | — | uncertain significance |
| rs2544839929 | 15:66,615,036 | G/A | — | uncertain significance |
| rs202123708 | 15:66,615,043 | A/G | — | uncertain significance |
| rs200498297 | 15:66,615,091 | C/T | — | uncertain significance |
| rs201473278 | 15:66,615,092 | G/T | — | uncertain significance |
| rs1448960814 | 15:66,615,147 | A/C | — | uncertain significance |
| rs2092899798 | 15:66,615,178 | T/G | — | uncertain significance |
| rs1325453702 | 15:66,615,191 | A/C | — | uncertain significance |
| rs1222749593 | 15:66,615,211 | A/G | — | uncertain significance |
| rs142139052 | 15:66,615,857 | G/A | — | uncertain significance |
| rs768644711 | 15:66,615,859 | C/T | — | uncertain significance |
| rs369988387 | 15:66,615,860 | G/A | — | uncertain significance |
| rs200501486 | 15:66,615,868 | A/C | — | uncertain significance |
| rs1463007484 | 15:66,615,916 | G/A | — | uncertain significance |
| rs146642941 | 15:66,618,269 | T/C | — | uncertain significance |
| rs770718433 | 15:66,618,352 | C/G | — | uncertain significance |
| rs375765851 | 15:66,618,404 | A/G | — | uncertain significance |
| rs138804635 | 15:66,618,471 | G/A | — | uncertain significance |
| rs374290496 | 15:66,618,666 | A/C | — | uncertain significance |
| rs2544856368 | 15:66,618,695 | G/C | — | uncertain significance |
| rs372229333 | 15:66,621,325 | C/T | — | uncertain significance |
| rs35711894 | 15:66,621,382 | A/G | — | likely benign |
| rs2092973244 | 15:66,621,599 | A/G | — | uncertain significance |
| rs772589174 | 15:66,621,628 | G/A | — | uncertain significance |
| rs751694620 | 15:66,624,222 | C/A | — | uncertain significance |
| rs367587318 | 15:66,624,237 | T/G | — | uncertain significance |
| rs755903291 | 15:66,624,258 | A/G | — | uncertain significance |
| rs770548426 | 15:66,624,267 | A/G | — | uncertain significance |
| rs147697627 | 15:66,624,289 | A/T | — | uncertain significance |
| rs763221320 | 15:66,624,290 | G/T | — | uncertain significance |
| rs141291614 | 15:66,624,294 | C/T | — | uncertain significance |
| rs777614247 | 15:66,624,300 | A/G | — | uncertain significance |
| rs8032684 | 15:66,624,854 | A/T | — | — |
| rs771222281 | 15:66,625,076 | T/C | — | uncertain significance |
| rs764256881 | 15:66,625,111 | G/A | — | uncertain significance |
| rs149109779 | 15:66,625,140 | T/A | — | uncertain significance |
| rs141163737 | 15:66,625,223 | C/T | — | uncertain significance |
| rs771315275 | 15:66,625,501 | G/C | — | uncertain significance |
| rs370479708 | 15:66,625,561 | C/T | — | likely benign |
| rs143709249 | 15:66,625,562 | G/C | — | uncertain significance |
| rs2544891598 | 15:66,625,571 | A/G | — | uncertain significance |
| rs193920782 | 15:66,625,574 | G/A | — | uncertain significance |
| rs916113197 | 15:66,625,622 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.