DIS3L2

DIS3 like 3'-5' exoribonuclease 2

Summary

The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]

Known Variants1,733 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs143944819	2:232,825,146	A/C	—	—
rs769255550	2:232,826,319	C/G	—	uncertain significance
rs886055767	2:232,826,340	C/T	—	uncertain significance
rs924366103	2:232,826,426	C/G	—	uncertain significance
rs549994066	2:232,826,427	T/A	—	uncertain significance
rs535486739	2:232,826,467	G/A	—	uncertain significance
rs748871880	2:232,826,474	C/T	—	uncertain significance
rs191498594	2:232,834,254	C/G	intron variant	—
rs77245717	2:232,837,942	C/T	intron variant	—
rs12988095	2:232,838,728	G/A	downstream gene variant	—
rs180859514	2:232,843,212	A/G	coding sequence variant	—
rs537201672	2:232,847,962	A/G	—	—
rs148499822	2:232,852,521	G/A	regulatory region variant	—
rs114392695	2:232,874,737	C/A	intron variant	—
rs114491317	2:232,879,560	C/T	—	likely benign
rs886055768	2:232,879,571	G/A	—	uncertain significance
rs750961522	2:232,879,586	A/G	—	uncertain significance
rs754758868	2:232,879,638	A/T	—	uncertain significance
rs2469593917	2:232,879,646	T/C	—	likely benign
rs1431824314	2:232,879,647	C/A	—	uncertain significance
rs1694312197	2:232,879,648	C/G	—	uncertain significance
rs2469593932	2:232,879,651	A/G	—	uncertain significance
rs1694312412	2:232,879,654	A/G	—	uncertain significance
rs2106220724	2:232,879,656	A/G	—	uncertain significance
rs2469593949	2:232,879,657	G/C	—	uncertain significance
rs2469593960	2:232,879,660	T/G	—	uncertain significance
rs2106220732	2:232,879,664	C/T	—	likely benign
rs574055101	2:232,879,665	C/T	—	uncertain significance
rs1170188523	2:232,879,667	C/T	—	likely benign
rs751777329	2:232,879,668	C/T	—	uncertain significance
rs1574812165	2:232,879,669	G/A	—	uncertain significance
rs757314939	2:232,879,670	G/A	—	likely benign
rs723044	2:232,879,671	C/T	—	uncertain significance
rs770359206	2:232,879,673	C/G	—	likely benign
rs554832054	2:232,879,674	C/A	—	uncertain significance
rs2106220790	2:232,879,679	G/A	—	likely benign
rs1559542316	2:232,879,680	A/G	—	uncertain significance
rs749719015	2:232,879,681	C/A	—	uncertain significance
rs974812898	2:232,879,683	C/A	—	uncertain significance
rs769111524	2:232,879,684	C/G	—	uncertain significance
rs1574812219	2:232,879,686	A/G	—	uncertain significance
rs1694314479	2:232,879,689	G/A	—	uncertain significance
rs773905464	2:232,879,692	A/G	—	uncertain significance
rs2469594122	2:232,879,696	A/G	—	likely benign
rs2106220834	2:232,879,699	G/T	—	likely benign
rs922102239	2:232,879,705	T/C	—	likely benign
rs2106220848	2:232,879,706	G/A	—	likely benign
rs1445522295	2:232,880,204	T/C	—	likely benign
rs368468992	2:232,880,205	T/C	—	likely benign
rs1346099514	2:232,880,207	C/T	—	likely benign
rs774039141	2:232,880,208	T/C	—	likely benign
rs1399385539	2:232,880,209	G/A	—	likely benign
rs2106221478	2:232,880,211	C/G	—	likely benign
rs1459825302	2:232,880,213	C/T	—	likely benign
rs2106221482	2:232,880,215	T/C	—	likely benign
rs2469595432	2:232,880,219	T/G	—	likely benign
rs1559542792	2:232,880,220	C/A	—	likely benign
rs1276037942	2:232,880,224	G/A	—	uncertain significance
rs2469595461	2:232,880,225	T/A	—	uncertain significance
rs2469595468	2:232,880,226	G/A	—	uncertain significance
rs372201663	2:232,880,227	T/G	—	uncertain significance
rs375960593	2:232,880,229	T/C	—	uncertain significance
rs1694327799	2:232,880,230	C/G	—	uncertain significance
rs2469595496	2:232,880,233	C/T	—	uncertain significance
rs1694327880	2:232,880,234	T/G	—	likely benign
rs183463487	2:232,880,235	G/C	—	uncertain significance
rs2469595519	2:232,880,237	G/A	—	likely benign
rs886288172	2:232,880,238	G/C	—	uncertain significance
rs1004734586	2:232,880,239	C/G	—	uncertain significance
rs2469595546	2:232,880,242	G/C	—	uncertain significance
rs767500228	2:232,880,243	T/G	—	likely benign
rs1694328798	2:232,880,245	C/G	—	uncertain significance
rs780747005	2:232,880,250	G/C	—	uncertain significance
rs1694329034	2:232,880,251	A/G	—	uncertain significance
rs755318575	2:232,880,254	T/C	—	uncertain significance
rs2106221571	2:232,880,255	T/G	—	uncertain significance
rs779277888	2:232,880,256	G/C	—	uncertain significance
rs369080386	2:232,880,257	G/A	—	uncertain significance
rs1165526823	2:232,880,259	G/T	—	uncertain significance
rs2106221608	2:232,880,261	T/C	—	likely benign
rs901797759	2:232,880,263	C/T	—	uncertain significance
rs772722191	2:232,880,264	G/A	—	likely benign
rs2106221628	2:232,880,265	C/T	—	uncertain significance
rs2106221636	2:232,880,266	C/T	—	uncertain significance
rs746567735	2:232,880,268	G/C	—	uncertain significance
rs776585118	2:232,880,272	A/C	—	uncertain significance
rs764957786	2:232,880,273	C/T	—	likely benign
rs1694330394	2:232,880,275	A/G	—	uncertain significance
rs1694330552	2:232,880,278	A/T	—	uncertain significance
rs371477071	2:232,880,279	G/A	—	conflicting classifications of pathogenicity
rs1489163209	2:232,880,280	T/C	—	uncertain significance
rs1694330814	2:232,880,283	A/G	—	uncertain significance
rs1694330895	2:232,880,285	G/A	—	likely benign
rs1376481654	2:232,880,286	A/G	—	uncertain significance
rs1574812741	2:232,880,289	A/G	—	uncertain significance
rs1694331205	2:232,880,290	G/A	—	uncertain significance
rs1191453850	2:232,880,291	G/A	—	likely benign
rs762653147	2:232,880,298	C/T	—	pathogenic
rs767837521	2:232,880,299	G/A	—	uncertain significance
rs2469595787	2:232,880,303	G/T	—	uncertain significance

Showing 100 of 1,733 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.