DKK4
dickkopf Wnt signaling pathway inhibitor 4
Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs941530121 | 8:42,231,626 | T/C | — | uncertain significance |
| rs200776586 | 8:42,231,641 | A/C | — | uncertain significance |
| rs201291961 | 8:42,231,665 | G/A | — | uncertain significance |
| rs200364431 | 8:42,231,688 | C/T | — | uncertain significance |
| rs148982158 | 8:42,231,756 | T/G | — | uncertain significance |
| rs375323773 | 8:42,231,764 | A/G | — | uncertain significance |
| rs2073664 | 8:42,231,786 | G/A | synonymous variant | — |
| rs199600734 | 8:42,231,805 | G/A | — | uncertain significance |
| rs529642073 | 8:42,231,817 | C/T | — | uncertain significance |
| rs766494052 | 8:42,231,818 | G/T | — | uncertain significance |
| rs35249735 | 8:42,231,845 | C/A | — | uncertain significance |
| rs112583209 | 8:42,232,344 | C/T | — | likely benign |
| rs763523246 | 8:42,233,278 | G/A | — | uncertain significance |
| rs374249506 | 8:42,233,290 | C/T | — | likely benign |
| rs201984841 | 8:42,233,291 | G/A | — | uncertain significance |
| rs201742431 | 8:42,233,324 | C/A | — | uncertain significance |
| rs1824550370 | 8:42,233,335 | A/C | — | uncertain significance |
| rs1824578117 | 8:42,234,542 | C/T | — | uncertain significance |
| rs144528734 | 8:42,234,551 | C/T | — | uncertain significance |
| rs3763511 | 8:42,235,858 | G/A | upstream gene variant | — |
| rs77736087 | 8:42,237,304 | A/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.