DLEU2
deleted in lymphocytic leukemia 2
Summary
This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9596219 | 13:50,563,447 | C/T | intergenic variant | — |
| rs12583637 | 13:50,564,490 | C/T | — | — |
| rs35937141 | 13:50,581,922 | A/C | — | — |
| rs2066550 | 13:50,590,871 | A/T | — | — |
| rs150929481 | 13:50,592,459 | T/C | intron variant | — |
| rs9596226 | 13:50,609,238 | T/C | intron variant | — |
| rs2740545 | 13:50,626,759 | T/C | upstream gene variant | — |
| rs2760920 | 13:50,638,585 | A/C | — | — |
| rs2066572 | 13:50,648,487 | T/C | regulatory region variant | — |
| rs139370814 | 13:50,649,998 | C/T | regulatory region variant | — |
| rs763268500 | 13:50,655,089 | G/A | — | — |
| rs2066575 | 13:50,656,582 | T/C | missense variant | — |
| rs9526636 | 13:50,668,480 | G/A | upstream gene variant | — |
| rs75823898 | 13:50,669,173 | C/A | upstream gene variant | — |
| rs2066590 | 13:50,701,190 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.