DPP3
dipeptidyl peptidase 3
Summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Known Variants59 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2279864 | 11:66,247,844 | G/A | regulatory region variant | — |
| rs747987185 | 11:66,249,690 | A/C | — | uncertain significance |
| rs200777816 | 11:66,249,700 | A/G | — | uncertain significance |
| rs149689390 | 11:66,249,705 | A/G | — | uncertain significance |
| rs900201852 | 11:66,249,718 | G/A | — | uncertain significance |
| rs139018330 | 11:66,249,730 | G/A | — | uncertain significance |
| rs142478050 | 11:66,249,736 | C/G | — | uncertain significance |
| rs201658473 | 11:66,249,741 | C/T | — | uncertain significance |
| rs557697442 | 11:66,249,787 | G/A | — | uncertain significance |
| rs1247011196 | 11:66,249,838 | C/T | — | uncertain significance |
| rs536918372 | 11:66,249,888 | G/A | — | uncertain significance |
| rs11826683 | 11:66,249,898 | G/A | — | benign |
| rs201636331 | 11:66,249,927 | G/A | — | uncertain significance |
| rs187082477 | 11:66,252,639 | C/G | — | benign |
| rs929155985 | 11:66,252,645 | C/T | — | uncertain significance |
| rs2495642584 | 11:66,252,696 | C/A | — | uncertain significance |
| rs141227407 | 11:66,254,092 | G/A | — | uncertain significance |
| rs779074322 | 11:66,254,128 | C/T | — | uncertain significance |
| rs112484606 | 11:66,254,137 | C/A | — | benign |
| rs113216220 | 11:66,254,157 | C/G | — | benign |
| rs1555041476 | 11:66,254,814 | G/A | — | uncertain significance |
| rs746680575 | 11:66,255,424 | G/A | — | uncertain significance |
| rs780887994 | 11:66,258,732 | C/G | — | uncertain significance |
| rs779451383 | 11:66,258,774 | C/T | — | uncertain significance |
| rs762335511 | 11:66,258,798 | C/T | — | uncertain significance |
| rs200834438 | 11:66,258,810 | G/A | — | uncertain significance |
| rs149136081 | 11:66,258,813 | C/T | — | uncertain significance |
| rs142252193 | 11:66,258,814 | C/T | — | uncertain significance |
| rs764812384 | 11:66,259,005 | A/G | — | uncertain significance |
| rs368941305 | 11:66,259,037 | G/A | — | uncertain significance |
| rs1855390977 | 11:66,259,075 | C/A | — | uncertain significance |
| rs17849480 | 11:66,260,191 | C/T | — | benign |
| rs200473591 | 11:66,260,192 | G/A | — | uncertain significance |
| rs200517626 | 11:66,260,232 | G/A | — | uncertain significance |
| rs200674271 | 11:66,260,242 | G/A | — | likely benign |
| rs200126600 | 11:66,260,342 | G/C | — | uncertain significance |
| rs147519149 | 11:66,260,557 | G/A | — | benign |
| rs2495668646 | 11:66,260,582 | G/A | — | uncertain significance |
| rs775361424 | 11:66,260,615 | C/T | — | uncertain significance |
| rs147932251 | 11:66,260,623 | G/A | — | benign |
| rs76777675 | 11:66,261,044 | C/T | — | benign |
| rs201554759 | 11:66,261,099 | G/A | — | uncertain significance |
| rs147328602 | 11:66,262,711 | C/T | — | uncertain significance |
| rs34504069 | 11:66,262,944 | C/T | — | conflicting classifications of pathogenicity |
| rs760656237 | 11:66,263,112 | T/C | — | uncertain significance |
| rs1346296209 | 11:66,263,135 | G/A | — | uncertain significance |
| rs200417388 | 11:66,263,166 | G/A | — | uncertain significance |
| rs202040748 | 11:66,264,781 | G/T | — | uncertain significance |
| rs141613350 | 11:66,264,859 | G/A | — | uncertain significance |
| rs202163323 | 11:66,264,865 | C/T | — | uncertain significance |
| rs1297723472 | 11:66,264,922 | C/G | — | uncertain significance |
| rs114407249 | 11:66,272,128 | G/A | — | benign |
| rs746730453 | 11:66,272,153 | C/T | — | uncertain significance |
| rs150831495 | 11:66,272,158 | C/T | — | uncertain significance |
| rs200243081 | 11:66,272,197 | C/T | — | uncertain significance |
| rs139251036 | 11:66,272,198 | G/C | — | uncertain significance |
| rs773509372 | 11:66,273,953 | T/G | — | — |
| rs61561111 | 11:66,275,923 | T/C | upstream gene variant | — |
| rs201848080 | 11:66,276,636 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.