DPP4
dipeptidyl peptidase 4
Summary
The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]
Known Variants67 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs144519975 | 2:162,849,809 | C/G | missense variant | — |
| rs2468418888 | 2:162,849,840 | A/G | — | uncertain significance |
| rs12617656 | 2:162,851,147 | T/G | — | — |
| rs1280179299 | 2:162,851,522 | T/G | — | likely benign |
| rs2468423430 | 2:162,851,531 | A/C | — | uncertain significance |
| rs2468424404 | 2:162,851,825 | G/A | — | uncertain significance |
| rs4140685 | 2:162,852,079 | G/T | intron variant | — |
| rs181673904 | 2:162,859,409 | C/T | intron variant | — |
| rs200487335 | 2:162,862,269 | G/A | — | uncertain significance |
| rs2268891 | 2:162,865,068 | A/G | — | benign |
| rs759017895 | 2:162,865,099 | C/T | — | uncertain significance |
| rs17848910 | 2:162,865,124 | G/A | — | benign |
| rs201712012 | 2:162,865,127 | A/C | — | uncertain significance |
| rs41268649 | 2:162,865,133 | C/T | synonymous variant | — |
| rs200839327 | 2:162,865,134 | G/A | — | uncertain significance |
| rs115450134 | 2:162,865,748 | T/C | — | benign |
| rs1559707154 | 2:162,865,755 | C/A | — | uncertain significance |
| rs200298322 | 2:162,865,762 | T/C | — | uncertain significance |
| rs769994552 | 2:162,865,804 | G/T | — | uncertain significance |
| rs2468460040 | 2:162,868,337 | T/C | — | uncertain significance |
| rs1559708222 | 2:162,868,417 | A/G | — | uncertain significance |
| rs768094863 | 2:162,870,896 | G/A | — | likely benign |
| rs72868637 | 2:162,870,926 | T/C | — | likely benign |
| rs200348396 | 2:162,870,961 | T/C | — | uncertain significance |
| rs747418170 | 2:162,873,306 | T/A | — | uncertain significance |
| rs1682954511 | 2:162,873,644 | G/A | — | uncertain significance |
| rs780892873 | 2:162,875,331 | G/A | — | uncertain significance |
| rs1129599 | 2:162,875,349 | C/G | — | benign |
| rs374247997 | 2:162,875,726 | C/T | — | likely benign |
| rs201511821 | 2:162,875,760 | C/T | — | uncertain significance |
| rs200764195 | 2:162,876,766 | C/A | — | uncertain significance |
| rs150619694 | 2:162,877,128 | C/G | — | uncertain significance |
| rs199672034 | 2:162,877,139 | G/A | — | likely benign |
| rs748931174 | 2:162,879,299 | T/C | — | uncertain significance |
| rs1683260629 | 2:162,881,323 | G/T | — | uncertain significance |
| rs1189294526 | 2:162,881,337 | T/C | — | uncertain significance |
| rs760571427 | 2:162,881,346 | C/G | — | uncertain significance |
| rs200137356 | 2:162,881,406 | T/C | — | uncertain significance |
| rs2468491872 | 2:162,881,441 | T/C | — | uncertain significance |
| rs1683642242 | 2:162,890,084 | A/G | — | uncertain significance |
| rs200439038 | 2:162,890,097 | T/G | — | uncertain significance |
| rs56179129 | 2:162,890,142 | C/T | — | likely benign |
| rs748410926 | 2:162,890,145 | T/C | — | uncertain significance |
| rs7608798 | 2:162,890,217 | G/T | — | — |
| rs201266487 | 2:162,891,708 | T/G | — | uncertain significance |
| rs752437358 | 2:162,891,789 | C/T | — | uncertain significance |
| rs1210832910 | 2:162,894,843 | T/C | — | uncertain significance |
| rs1576056789 | 2:162,894,854 | C/A | — | not provided |
| rs1683889588 | 2:162,895,494 | G/C | — | uncertain significance |
| rs3788979 | 2:162,900,889 | C/T | intron variant | — |
| rs1684143520 | 2:162,902,088 | A/G | — | uncertain significance |
| rs1559720589 | 2:162,902,101 | T/A | — | uncertain significance |
| rs143806961 | 2:162,903,426 | A/G | — | uncertain significance |
| rs750539982 | 2:162,903,429 | G/A | — | uncertain significance |
| rs2468540365 | 2:162,903,453 | C/A | — | uncertain significance |
| rs199929717 | 2:162,903,460 | C/T | — | uncertain significance |
| rs755253532 | 2:162,903,510 | T/A | — | uncertain significance |
| rs748564561 | 2:162,903,516 | T/C | — | uncertain significance |
| rs149517088 | 2:162,903,919 | T/C | — | likely benign |
| rs200202090 | 2:162,903,988 | G/A | — | uncertain significance |
| rs17848916 | 2:162,904,384 | A/C | intron variant | — |
| rs6741949 | 2:162,910,223 | G/C | regulatory region variant | — |
| rs67399148 | 2:162,913,166 | T/C | intron variant | — |
| rs17575 | 2:162,929,922 | C/T | — | benign |
| rs148524083 | 2:162,929,955 | C/T | — | benign |
| rs17574 | 2:162,929,979 | A/G | synonymous variant | — |
| rs13015258 | 2:162,930,725 | T/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.