DPP8
dipeptidyl peptidase 8
Summary
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs143814405 | 15:65,734,465 | T/C | downstream gene variant | — |
| rs7227 | 15:65,734,856 | G/C | 3 prime UTR variant | — |
| rs34511941 | 15:65,741,512 | T/G | — | — |
| rs28574727 | 15:65,742,390 | C/T | intron variant | — |
| rs12909009 | 15:65,743,050 | A/G | intron variant | — |
| rs2547875989 | 15:65,744,437 | C/T | — | uncertain significance |
| rs778263996 | 15:65,748,580 | C/T | — | uncertain significance |
| rs581694 | 15:65,749,680 | T/C | upstream gene variant | — |
| rs369179039 | 15:65,756,170 | G/A | — | uncertain significance |
| rs117085177 | 15:65,758,918 | G/A | intron variant | — |
| rs1435028919 | 15:65,759,103 | A/T | — | uncertain significance |
| rs370549371 | 15:65,759,441 | G/C | — | uncertain significance |
| rs758254879 | 15:65,759,470 | T/C | — | uncertain significance |
| rs780061945 | 15:65,759,474 | C/T | — | uncertain significance |
| rs74561645 | 15:65,759,542 | C/T | — | uncertain significance |
| rs760756541 | 15:65,759,555 | C/T | — | uncertain significance |
| rs147909400 | 15:65,759,557 | T/C | — | uncertain significance |
| rs185464262 | 15:65,766,594 | C/T | — | uncertain significance |
| rs767334235 | 15:65,771,241 | G/A | — | uncertain significance |
| rs369230835 | 15:65,772,622 | A/G | — | uncertain significance |
| rs1469647063 | 15:65,772,655 | C/A | — | uncertain significance |
| rs569438278 | 15:65,772,725 | G/C | — | uncertain significance |
| rs377350851 | 15:65,773,913 | T/C | — | uncertain significance |
| rs144639396 | 15:65,773,944 | C/T | — | uncertain significance |
| rs2548058352 | 15:65,777,460 | T/G | — | uncertain significance |
| rs551740987 | 15:65,780,132 | C/T | — | uncertain significance |
| rs367666845 | 15:65,782,624 | C/T | — | uncertain significance |
| rs144405811 | 15:65,782,625 | A/G | — | uncertain significance |
| rs191927852 | 15:65,785,697 | G/T | intron variant | — |
| rs1245436559 | 15:65,790,225 | C/T | — | uncertain significance |
| rs144636635 | 15:65,790,237 | G/C | — | uncertain significance |
| rs766819453 | 15:65,790,243 | A/G | — | uncertain significance |
| rs760257323 | 15:65,790,319 | T/C | — | uncertain significance |
| rs776158897 | 15:65,790,341 | T/G | — | uncertain significance |
| rs200120025 | 15:65,792,945 | G/A | — | uncertain significance |
| rs559775915 | 15:65,799,610 | A/G | — | uncertain significance |
| rs995299551 | 15:65,799,625 | C/T | — | uncertain significance |
| rs2070891486 | 15:65,804,641 | T/C | — | uncertain significance |
| rs1295539241 | 15:65,804,776 | C/T | — | uncertain significance |
| rs1045335342 | 15:65,804,825 | T/C | — | uncertain significance |
| rs148134824 | 15:65,807,996 | G/A | — | uncertain significance |
| rs767018635 | 15:65,808,013 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.