DUS2
dihydrouridine synthase 2
Summary
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs375337192 | 16:68,072,033 | C/T | — | uncertain significance |
| rs2544636054 | 16:68,072,051 | A/C | — | uncertain significance |
| rs147235496 | 16:68,083,442 | G/A | — | uncertain significance |
| rs116906005 | 16:68,084,063 | C/T | intron variant | — |
| rs746996249 | 16:68,088,514 | G/C | — | uncertain significance |
| rs141092300 | 16:68,100,230 | C/T | — | uncertain significance |
| rs2285912 | 16:68,100,461 | C/G | — | — |
| rs143329208 | 16:68,100,496 | C/T | — | uncertain significance |
| rs767190581 | 16:68,100,526 | G/A | — | uncertain significance |
| rs372818688 | 16:68,104,041 | C/T | — | uncertain significance |
| rs561510268 | 16:68,104,051 | G/A | — | uncertain significance |
| rs746726616 | 16:68,104,860 | A/G | — | uncertain significance |
| rs978943511 | 16:68,104,932 | C/G | — | uncertain significance |
| rs145844992 | 16:68,104,952 | A/G | — | uncertain significance |
| rs147080316 | 16:68,104,995 | A/G | — | uncertain significance |
| rs138485465 | 16:68,107,938 | C/T | — | uncertain significance |
| rs766723286 | 16:68,107,940 | G/A | — | uncertain significance |
| rs753922635 | 16:68,107,953 | A/G | — | uncertain significance |
| rs779701580 | 16:68,108,010 | C/T | — | uncertain significance |
| rs2034142172 | 16:68,109,275 | G/A | — | uncertain significance |
| rs925237494 | 16:68,109,348 | G/C | — | uncertain significance |
| rs1158672616 | 16:68,109,362 | C/T | — | uncertain significance |
| rs762449315 | 16:68,110,588 | G/A | — | uncertain significance |
| rs779269977 | 16:68,112,367 | G/A | — | uncertain significance |
| rs144122445 | 16:68,112,382 | T/A | — | uncertain significance |
| rs148640115 | 16:68,112,696 | G/A | — | uncertain significance |
| rs1486080979 | 16:68,112,759 | G/A | — | uncertain significance |
| rs2544680390 | 16:68,112,764 | A/T | — | uncertain significance |
| rs140584572 | 16:68,112,834 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.