DUSP18
dual specificity phosphatase 18
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs997453283 | 22:31,059,428 | A/G | — | uncertain significance |
| rs142285924 | 22:31,059,444 | G/A | — | uncertain significance |
| rs764799988 | 22:31,059,458 | T/C | — | uncertain significance |
| rs142746950 | 22:31,059,498 | G/A | — | uncertain significance |
| rs147361219 | 22:31,059,504 | T/C | — | uncertain significance |
| rs1251831323 | 22:31,059,566 | C/T | — | uncertain significance |
| rs754173853 | 22:31,059,579 | G/A | — | uncertain significance |
| rs768947169 | 22:31,059,689 | A/C | — | uncertain significance |
| rs200346696 | 22:31,059,695 | C/T | — | uncertain significance |
| rs756322739 | 22:31,059,756 | G/C | — | uncertain significance |
| rs199672327 | 22:31,059,759 | G/A | — | uncertain significance |
| rs200899592 | 22:31,059,770 | G/A | — | uncertain significance |
| rs2088559950 | 22:31,059,789 | G/C | — | uncertain significance |
| rs760861702 | 22:31,059,857 | T/C | — | uncertain significance |
| rs760671397 | 22:31,059,954 | G/A | — | uncertain significance |
| rs145095975 | 22:31,059,974 | C/T | — | uncertain significance |
| rs779902558 | 22:31,059,977 | G/A | — | uncertain significance |
| rs34779325 | 22:31,064,736 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.