DYRK3
dual specificity tyrosine phosphorylation regulated kinase 3
Summary
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Known Variants25 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs141657852 | 1:206,811,048 | C/T | — | uncertain significance |
| rs12073237 | 1:206,813,060 | T/C | upstream gene variant | — |
| rs201321895 | 1:206,820,746 | A/G | — | uncertain significance |
| rs139024809 | 1:206,820,790 | A/T | — | uncertain significance |
| rs2529420390 | 1:206,820,901 | A/C | — | uncertain significance |
| rs2529420479 | 1:206,820,922 | G/A | — | uncertain significance |
| rs201452638 | 1:206,821,100 | A/G | — | uncertain significance |
| rs55721647 | 1:206,821,123 | G/T | — | uncertain significance |
| rs782789145 | 1:206,821,260 | G/T | — | uncertain significance |
| rs56374404 | 1:206,821,285 | C/T | — | uncertain significance |
| rs202193987 | 1:206,821,307 | G/A | — | uncertain significance |
| rs199718118 | 1:206,821,333 | G/A | — | uncertain significance |
| rs2529423503 | 1:206,821,336 | A/G | — | uncertain significance |
| rs201468157 | 1:206,821,370 | A/G | — | uncertain significance |
| rs782269982 | 1:206,821,380 | A/T | — | likely benign |
| rs200692265 | 1:206,821,448 | A/G | — | uncertain significance |
| rs200513273 | 1:206,821,480 | C/T | — | uncertain significance |
| rs782022196 | 1:206,821,616 | C/T | — | uncertain significance |
| rs782306516 | 1:206,821,627 | G/A | — | uncertain significance |
| rs1316203487 | 1:206,821,720 | T/C | — | uncertain significance |
| rs145519561 | 1:206,821,952 | G/A | — | uncertain significance |
| rs782619318 | 1:206,822,068 | G/T | — | uncertain significance |
| rs200378422 | 1:206,822,071 | C/T | — | uncertain significance |
| rs1175213193 | 1:206,822,144 | A/G | — | uncertain significance |
| rs782671806 | 1:206,822,252 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.