E2F6
E2F transcription factor 6
Summary
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Known Variants14 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11687178 | 2:11,584,197 | C/A | downstream gene variant | — |
| rs11203 | 2:11,586,035 | G/C | — | — |
| rs1047392 | 2:11,586,219 | A/G | 3 prime UTR variant | — |
| rs2527514075 | 2:11,586,628 | T/G | — | uncertain significance |
| rs779722761 | 2:11,587,779 | C/T | — | uncertain significance |
| rs2527536108 | 2:11,590,173 | C/T | — | uncertain significance |
| rs372426239 | 2:11,591,866 | G/C | — | uncertain significance |
| rs375413383 | 2:11,591,916 | T/C | — | uncertain significance |
| rs780272589 | 2:11,593,765 | T/C | — | uncertain significance |
| rs750544995 | 2:11,593,792 | C/T | — | uncertain significance |
| rs374798482 | 2:11,593,807 | G/A | — | uncertain significance |
| rs141179047 | 2:11,605,914 | T/G | — | uncertain significance |
| rs1672162016 | 2:11,605,920 | G/A | — | uncertain significance |
| rs1168981860 | 2:11,605,933 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.