EFNA4
ephrin A4
Summary
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin that has been implicated in proliferation and metastasis of several types of cancers. [provided by RefSeq, May 2022]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1002230 | 1:155,036,229 | G/A | — | — |
| rs760930080 | 1:155,036,404 | T/A | — | uncertain significance |
| rs764545146 | 1:155,036,407 | C/A | — | uncertain significance |
| rs2526437395 | 1:155,036,430 | G/A | — | likely benign |
| rs371052923 | 1:155,036,431 | G/A | — | benign |
| rs142249822 | 1:155,039,225 | G/C | — | uncertain significance |
| rs148289726 | 1:155,039,270 | C/T | — | likely benign |
| rs541082385 | 1:155,039,308 | G/A | — | likely benign |
| rs138277393 | 1:155,039,321 | A/G | — | uncertain significance |
| rs142999275 | 1:155,039,367 | G/A | — | uncertain significance |
| rs1286500741 | 1:155,039,372 | T/G | — | uncertain significance |
| rs544929070 | 1:155,039,389 | C/T | — | likely benign |
| rs1663064781 | 1:155,039,417 | T/C | — | uncertain significance |
| rs1422554226 | 1:155,039,439 | C/T | — | uncertain significance |
| rs143886639 | 1:155,039,441 | C/A | — | likely benign |
| rs761582524 | 1:155,039,452 | C/T | — | likely benign |
| rs114301457 | 1:155,039,464 | C/T | — | likely benign |
| rs752848379 | 1:155,039,478 | C/G | — | uncertain significance |
| rs749656720 | 1:155,039,506 | G/A | — | likely benign |
| rs151179474 | 1:155,039,849 | G/A | — | likely benign |
| rs2102443869 | 1:155,039,872 | G/T | — | uncertain significance |
| rs757589642 | 1:155,039,876 | G/C | — | uncertain significance |
| rs199918580 | 1:155,041,330 | G/T | — | uncertain significance |
| rs2526465029 | 1:155,041,331 | T/A | — | uncertain significance |
| rs1368166854 | 1:155,041,359 | C/T | — | uncertain significance |
| rs145129032 | 1:155,041,449 | T/G | — | likely benign |
| rs201215681 | 1:155,041,489 | C/G | — | likely benign |
| rs889300332 | 1:155,041,542 | G/C | — | uncertain significance |
| rs1021875220 | 1:155,041,570 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.