EIF4A1
eukaryotic translation initiation factor 4A1
Summary
Enables double-stranded RNA binding activity and translation initiation factor activity. Involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs199974690 | 17:7,476,179 | C/T | — | uncertain significance |
| rs745767783 | 17:7,477,589 | A/G | — | uncertain significance |
| rs62059824 | 17:7,478,213 | C/G | — | — |
| rs7358 | 17:7,478,498 | G/A | — | benign |
| rs2508474950 | 17:7,478,544 | G/A | — | uncertain significance |
| rs1418798284 | 17:7,480,776 | C/T | — | uncertain significance |
| rs373864323 | 17:7,480,879 | A/G | — | uncertain significance |
| rs1055081896 | 17:7,481,169 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.