EIF4E2
eukaryotic translation initiation factor 4E family member 2
Summary
Enables RNA 7-methylguanosine cap binding activity; mRNA cap binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of translational initiation; negative regulation of type I interferon-mediated signaling pathway; and rescue of stalled ribosome. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1692275723 | 2:233,415,453 | G/A | — | uncertain significance |
| rs377735542 | 2:233,421,203 | C/T | — | uncertain significance |
| rs148255880 | 2:233,422,610 | C/T | — | uncertain significance |
| rs769552669 | 2:233,422,621 | C/T | — | uncertain significance |
| rs754375724 | 2:233,422,666 | G/A | — | uncertain significance |
| rs1656402 | 2:233,426,526 | C/T | intron variant | — |
| rs745875029 | 2:233,428,981 | A/G | — | uncertain significance |
| rs2469440979 | 2:233,428,990 | G/A | — | uncertain significance |
| rs921725664 | 2:233,428,994 | G/A | — | uncertain significance |
| rs187855722 | 2:233,430,965 | C/T | intron variant | — |
| rs2469446480 | 2:233,431,539 | G/A | — | uncertain significance |
| rs2469447420 | 2:233,431,834 | C/T | — | uncertain significance |
| rs1253747485 | 2:233,431,849 | G/A | — | uncertain significance |
| rs779332394 | 2:233,431,869 | C/T | — | uncertain significance |
| rs140152833 | 2:233,433,680 | A/G | — | uncertain significance |
| rs779845297 | 2:233,433,708 | C/G | — | uncertain significance |
| rs146216550 | 2:233,433,710 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.