ENDOG

endonuclease G

Summary

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

Known Variants25 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs10988130	9:131,579,579	A/G	upstream gene variant	—
rs2490911080	9:131,581,013	G/T	—	uncertain significance
rs1327013077	9:131,581,087	G/C	—	uncertain significance
rs2490911745	9:131,581,150	G/A	—	uncertain significance
rs757963132	9:131,581,173	G/C	—	likely benign
rs777462203	9:131,581,204	T/G	—	uncertain significance
rs746520947	9:131,581,226	G/T	—	uncertain significance
rs542727367	9:131,581,264	C/T	—	uncertain significance
rs970057720	9:131,581,292	G/C	—	uncertain significance
rs762857548	9:131,581,312	G/C	—	uncertain significance
rs2490912841	9:131,581,352	C/T	—	uncertain significance
rs2490918735	9:131,583,027	C/T	—	uncertain significance
rs528071859	9:131,583,052	T/C	—	uncertain significance
rs547914635	9:131,583,066	C/T	—	uncertain significance
rs556705072	9:131,583,093	G/A	—	uncertain significance
rs2490924967	9:131,584,643	G/C	—	uncertain significance
rs55985529	9:131,584,649	C/T	—	benign
rs369635561	9:131,584,723	A/G	—	uncertain significance
rs61737988	9:131,584,729	G/T	—	benign
rs61737987	9:131,584,732	C/T	—	benign
rs2490925430	9:131,584,752	C/T	—	uncertain significance
rs755497118	9:131,584,779	C/T	—	uncertain significance
rs142344729	9:131,584,780	G/A	—	uncertain significance
rs371060113	9:131,584,816	C/T	—	uncertain significance
rs750255865	9:131,584,849	G/A	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.