ENPP7

ectonucleotide pyrophosphatase/phosphodiesterase 7

Summary

The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]

Known Variants40 total

rsidPosition (GRCh37)AllelesClassClinVar
rs807653317:77,704,314C/G
rs55144848117:77,704,942C/Tuncertain significance
rs19392082617:77,704,969C/Tuncertain significance
rs78225055117:77,705,037G/Cuncertain significance
rs14240103317:77,705,046G/Auncertain significance
rs78212269317:77,705,095G/Auncertain significance
rs1186869617:77,706,406A/Gregulatory region variant
rs11328633117:77,707,282C/Tregulatory region variant
rs13830517617:77,707,364G/Tuncertain significance
rs14593172617:77,707,422G/Auncertain significance
rs37688035717:77,708,906C/Tuncertain significance
rs78180706917:77,709,091C/Tuncertain significance
rs15075522017:77,709,103C/Tuncertain significance
rs78203316717:77,709,119T/Auncertain significance
rs20153296017:77,709,133G/Auncertain significance
rs78275313717:77,709,151G/Auncertain significance
rs251541998117:77,709,160A/Guncertain significance
rs76585557217:77,709,191C/Tuncertain significance
rs37262365017:77,709,206G/Alikely benign
rs78215866917:77,709,214G/Auncertain significance
rs78263704317:77,709,253C/Tuncertain significance
rs75102272017:77,709,287C/Tuncertain significance
rs78205115917:77,709,374A/Guncertain significance
rs78250556217:77,709,397T/Clikely benign
rs14518698117:77,709,406G/Auncertain significance
rs251542095017:77,709,416C/Auncertain significance
rs37615236717:77,709,440A/Guncertain significance
rs56790091117:77,709,445G/Auncertain significance
rs20164314617:77,710,915G/Auncertain significance
rs13971999717:77,710,990C/Tlikely benign
rs14850445417:77,711,018A/Gmissense variant
rs78211319517:77,711,020G/Auncertain significance
rs78203515117:77,711,030T/Clikely benign
rs78204807717:77,711,032G/Cuncertain significance
rs78248493517:77,711,718C/Tuncertain significance
rs78266306517:77,711,727C/Tlikely benign
rs14136972417:77,711,798G/Auncertain significance
rs78245456917:77,711,819G/Alikely benign
rs78244397917:77,711,840G/Auncertain significance
rs6207788417:77,713,416A/Gregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.