EPX

eosinophil peroxidase

Summary

This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]

Known Variants75 total

rsidPosition (GRCh37)AllelesClassClinVar
rs136341547117:56,270,221C/Tlikely benign
rs3455373617:56,270,425G/Abenign
rs13932256617:56,270,438G/Abenign
rs77293095117:56,270,454G/Cuncertain significance
rs20011280017:56,270,497A/Glikely benign
rs77299785517:56,270,749G/Auncertain significance
rs75072943717:56,270,874C/Auncertain significance
rs37396413217:56,270,889G/Alikely benign
rs75989940817:56,271,098C/Tuncertain significance
rs56356039717:56,271,137C/Guncertain significance
rs14103847617:56,271,168C/Guncertain significance
rs37040423817:56,271,179C/Tuncertain significance
rs3606618617:56,271,200C/Tbenign
rs74535339617:56,272,329G/Auncertain significance
rs125242679417:56,272,343C/Auncertain significance
rs14867114817:56,272,362A/Glikely benign
rs53014633917:56,272,383G/Auncertain significance
rs77449900817:56,272,389G/Auncertain significance
rs148306898817:56,272,398T/Cuncertain significance
rs6263662117:56,272,455C/Tuncertain significance
rs77565705117:56,272,472A/Guncertain significance
rs76220308317:56,272,481G/Auncertain significance
rs3561769217:56,272,501C/Abenign
rs3459942617:56,272,532G/Alikely benign
rs12143456617:56,274,355G/Amissense variantaffects
rs3397125817:56,274,373C/Tbenign
rs19978651717:56,274,396A/Cuncertain significance
rs75636210317:56,274,408G/Alikely benign
rs20141973317:56,274,409C/Tuncertain significance
rs14841473417:56,274,413C/Tbenign
rs14961064917:56,274,420T/Clikely benign
rs77439491717:56,274,429G/Auncertain significance
rs77529010117:56,274,530C/Auncertain significance
rs3541921917:56,274,563C/Guncertain significance
rs74537567717:56,274,564G/Auncertain significance
rs57382798317:56,274,588C/Tuncertain significance
rs76486593017:56,274,598G/Auncertain significance
rs76107143717:56,276,461A/Guncertain significance
rs20107557417:56,276,470G/Auncertain significance
rs14366469517:56,276,481G/Auncertain significance
rs75755169017:56,276,491G/Auncertain significance
rs18441919417:56,276,503G/Auncertain significance
rs13997311917:56,276,535C/Tuncertain significance
rs13928462517:56,276,546G/Auncertain significance
rs76817639017:56,276,952G/Auncertain significance
rs196831101217:56,276,993G/Cuncertain significance
rs36884468717:56,277,024C/Tuncertain significance
rs20183527217:56,277,030G/Auncertain significance
rs76821164617:56,277,065C/Tuncertain significance
rs121844229517:56,277,095C/Tuncertain significance
rs76455437417:56,277,102C/Tuncertain significance
rs20014631417:56,277,110C/Auncertain significance
rs100383029417:56,277,141G/Auncertain significance
rs37585973317:56,277,600A/Guncertain significance
rs54939609217:56,277,639C/Tuncertain significance
rs36977409917:56,277,640G/Auncertain significance
rs124806063617:56,277,667T/Cuncertain significance
rs15057998917:56,277,684C/Tlikely benign
rs77818995017:56,277,735A/Cuncertain significance
rs36962237417:56,277,738C/Tuncertain significance
rs230231117:56,280,447A/Tbenign
rs76561913617:56,280,483C/Guncertain significance
rs37213344117:56,280,568T/Cuncertain significance
rs138656892917:56,280,591G/Auncertain significance
rs14476845517:56,280,605G/Abenign
rs196836575117:56,280,606C/Tuncertain significance
rs14110430717:56,280,667G/Auncertain significance
rs14105542617:56,280,675G/Amissense variantaffects
rs20126579217:56,281,589G/Cuncertain significance
rs53720415517:56,281,600G/Auncertain significance
rs76751915217:56,281,602G/Auncertain significance
rs15008597017:56,281,624G/Auncertain significance
rs19183633917:56,281,708C/Tuncertain significance
rs77562309517:56,281,710A/Tuncertain significance
rs76508715717:56,281,731G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.