ERP44

endoplasmic reticulum protein 44

Summary

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

Known Variants23 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7461069729:102,744,907C/Tuncertain significance
rs7499032379:102,744,973C/Tuncertain significance
rs7560178879:102,747,314G/Auncertain significance
rs7584874849:102,747,326C/Tuncertain significance
rs5717141959:102,761,469C/A
rs7498343439:102,768,917A/Cuncertain significance
rs7540951419:102,769,871A/Tuncertain significance
rs1510328519:102,778,676A/Cmissense variant
rs7685837729:102,780,594C/Guncertain significance
rs47427799:102,781,837A/Cintron variant
rs7569766659:102,782,905C/Auncertain significance
rs7680739029:102,782,997A/Guncertain significance
rs3759030149:102,783,006T/Cuncertain significance
rs3686848659:102,784,334G/Auncertain significance
rs18305964799:102,784,369G/Tuncertain significance
rs3723248859:102,784,463T/Cuncertain significance
rs18305989059:102,784,481C/Tuncertain significance
rs70289399:102,808,685A/Gintron variant
rs7461301399:102,814,737T/Cuncertain significance
rs47433829:102,817,841C/Tintron variant
rs1430349609:102,820,138T/Cuncertain significance
rs1385128499:102,822,438G/Auncertain significance
rs7481120399:102,861,089G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.