FAR2
fatty acyl-CoA reductase 2
Summary
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs139209786 | 12:29,308,228 | T/A | intron variant | — |
| rs568970025 | 12:29,362,019 | A/G | — | — |
| rs4931170 | 12:29,388,772 | A/G | intron variant | — |
| rs141985647 | 12:29,423,410 | G/A | — | uncertain significance |
| rs1311573372 | 12:29,423,512 | G/A | — | uncertain significance |
| rs1303204479 | 12:29,423,518 | C/A | — | uncertain significance |
| rs771178026 | 12:29,423,521 | A/G | — | uncertain significance |
| rs751436028 | 12:29,423,548 | G/A | — | uncertain significance |
| rs2015599 | 12:29,435,480 | G/A | regulatory region variant | — |
| rs10771511 | 12:29,437,217 | T/G | — | — |
| rs370787314 | 12:29,446,239 | G/C | — | uncertain significance |
| rs1348703872 | 12:29,446,249 | A/G | — | uncertain significance |
| rs754564412 | 12:29,446,254 | G/A | — | uncertain significance |
| rs2498183677 | 12:29,446,335 | A/T | — | uncertain significance |
| rs780215182 | 12:29,449,997 | C/G | — | uncertain significance |
| rs778426836 | 12:29,460,665 | C/G | — | uncertain significance |
| rs181186551 | 12:29,463,953 | C/T | — | benign |
| rs1949341682 | 12:29,463,987 | A/G | — | uncertain significance |
| rs868406660 | 12:29,464,036 | G/A | — | uncertain significance |
| rs369960829 | 12:29,464,039 | A/G | — | uncertain significance |
| rs2498268026 | 12:29,464,821 | A/T | — | uncertain significance |
| rs1038750023 | 12:29,469,791 | A/G | — | uncertain significance |
| rs371118455 | 12:29,469,891 | G/A | — | uncertain significance |
| rs769300762 | 12:29,474,768 | A/G | — | uncertain significance |
| rs1023732880 | 12:29,474,790 | G/A | — | uncertain significance |
| rs184375580 | 12:29,474,808 | C/T | — | uncertain significance |
| rs755213222 | 12:29,474,856 | G/A | — | uncertain significance |
| rs538778348 | 12:29,477,358 | C/G | — | — |
| rs146589456 | 12:29,485,568 | G/A | — | benign |
| rs2498339853 | 12:29,485,626 | G/T | — | uncertain significance |
| rs767224864 | 12:29,486,647 | C/G | — | uncertain significance |
| rs375739748 | 12:29,486,702 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.