FARP1
FERM, ARH/RhoGEF and pleckstrin domain protein 1
Summary
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Known Variants74 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs285098 | 13:98,827,035 | G/C | downstream gene variant | — |
| rs9556893 | 13:98,831,595 | C/G | upstream gene variant | — |
| rs9554446 | 13:98,859,019 | T/A | regulatory region variant | — |
| rs369946560 | 13:98,865,515 | A/G | — | uncertain significance |
| rs771105203 | 13:98,865,558 | G/A | — | uncertain significance |
| rs372775592 | 13:98,906,846 | G/T | — | — |
| rs4318070 | 13:98,960,762 | C/T | intron variant | — |
| rs688872 | 13:98,966,317 | A/G | intron variant | — |
| rs9584805 | 13:98,994,030 | A/G | intron variant | — |
| rs747461832 | 13:98,996,119 | C/T | — | uncertain significance |
| rs188276647 | 13:99,017,676 | G/A | — | uncertain significance |
| rs370830451 | 13:99,020,415 | C/T | — | uncertain significance |
| rs186135754 | 13:99,022,717 | G/A | intron variant | — |
| rs2761371 | 13:99,022,740 | C/T | intron variant | — |
| rs749032986 | 13:99,030,125 | C/T | — | uncertain significance |
| rs75258648 | 13:99,030,126 | G/A | — | likely benign |
| rs2502167598 | 13:99,037,082 | T/A | — | uncertain significance |
| rs184642774 | 13:99,037,097 | A/G | — | uncertain significance |
| rs755676759 | 13:99,037,971 | G/A | — | uncertain significance |
| rs2502171906 | 13:99,037,981 | G/A | — | uncertain significance |
| rs150061718 | 13:99,038,001 | C/T | missense variant | — |
| rs775624327 | 13:99,043,092 | A/C | — | uncertain significance |
| rs2502207913 | 13:99,045,899 | A/G | — | uncertain significance |
| rs933464705 | 13:99,045,913 | C/G | — | uncertain significance |
| rs764049827 | 13:99,045,962 | T/C | — | uncertain significance |
| rs2502216168 | 13:99,047,513 | A/T | — | uncertain significance |
| rs749352073 | 13:99,047,571 | G/A | — | uncertain significance |
| rs772057395 | 13:99,047,580 | C/G | — | uncertain significance |
| rs1160164794 | 13:99,047,605 | C/G | — | uncertain significance |
| rs201301105 | 13:99,061,637 | C/T | — | uncertain significance |
| rs758405319 | 13:99,061,638 | G/A | — | likely benign |
| rs3736866 | 13:99,061,642 | G/T | — | uncertain significance |
| rs376255939 | 13:99,061,643 | G/C | — | uncertain significance |
| rs200968276 | 13:99,061,646 | G/T | — | uncertain significance |
| rs200978809 | 13:99,061,661 | A/G | — | uncertain significance |
| rs2502279435 | 13:99,061,745 | C/G | — | uncertain significance |
| rs375791003 | 13:99,061,751 | C/T | — | uncertain significance |
| rs139183577 | 13:99,061,772 | G/A | — | uncertain significance |
| rs749966621 | 13:99,063,070 | T/C | — | uncertain significance |
| rs368153237 | 13:99,064,203 | A/G | — | uncertain significance |
| rs561765791 | 13:99,064,278 | C/G | — | uncertain significance |
| rs767988593 | 13:99,076,830 | G/A | — | uncertain significance |
| rs771579289 | 13:99,083,367 | G/A | — | uncertain significance |
| rs1224295023 | 13:99,083,451 | A/C | — | uncertain significance |
| rs200285750 | 13:99,083,484 | G/C | — | uncertain significance |
| rs376434946 | 13:99,083,513 | G/A | — | uncertain significance |
| rs1892225845 | 13:99,087,838 | G/C | — | uncertain significance |
| rs200427694 | 13:99,087,849 | G/T | — | likely benign |
| rs140045465 | 13:99,087,930 | T/G | — | uncertain significance |
| rs1969794 | 13:99,090,168 | G/C | — | — |
| rs745779296 | 13:99,091,067 | C/T | — | uncertain significance |
| rs768787362 | 13:99,091,068 | G/A | — | uncertain significance |
| rs766670787 | 13:99,091,389 | G/C | — | uncertain significance |
| rs549931556 | 13:99,091,398 | C/T | — | uncertain significance |
| rs1174266777 | 13:99,091,419 | T/G | — | uncertain significance |
| rs61730893 | 13:99,091,441 | T/C | — | benign |
| rs577035758 | 13:99,092,264 | G/A | — | uncertain significance |
| rs530354815 | 13:99,092,382 | G/C | — | uncertain significance |
| rs199981965 | 13:99,092,417 | A/G | — | uncertain significance |
| rs9584848 | 13:99,092,443 | C/T | — | benign |
| rs144535978 | 13:99,092,927 | C/A | — | uncertain significance |
| rs751388367 | 13:99,092,942 | C/G | — | uncertain significance |
| rs765939276 | 13:99,093,013 | C/T | — | uncertain significance |
| rs2502425517 | 13:99,093,027 | G/T | — | uncertain significance |
| rs148511043 | 13:99,093,033 | C/A | — | uncertain significance |
| rs749424604 | 13:99,093,058 | G/A | — | uncertain significance |
| rs9517302 | 13:99,096,034 | A/T | — | — |
| rs769358579 | 13:99,098,392 | G/A | — | uncertain significance |
| rs951847519 | 13:99,098,425 | C/G | — | uncertain significance |
| rs758620517 | 13:99,098,445 | T/C | — | uncertain significance |
| rs751487619 | 13:99,098,452 | C/T | — | uncertain significance |
| rs750259401 | 13:99,098,960 | C/T | — | uncertain significance |
| rs2502479369 | 13:99,100,522 | C/T | — | uncertain significance |
| rs564920541 | 13:99,100,544 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.