FASN

fatty acid synthase

Summary

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Known Variants1,922 total

rsidPosition (GRCh37)AllelesClassClinVar
rs75979035017:80,037,029C/T—uncertain significance
rs76578416817:80,037,034G/A—likely benign
rs76621037717:80,037,039C/T—uncertain significance
rs114062417:80,037,040G/A—likely benign
rs145034553617:80,037,042G/A—uncertain significance
rs14977012517:80,037,058G/A—likely benign
rs135214117417:80,037,059C/A—uncertain significance
rs14683231917:80,037,064G/T—likely benign
rs138326977217:80,037,088G/A—likely benign
rs90593595517:80,037,106C/T—likely benign
rs75855214417:80,037,110C/T—uncertain significance
rs77797108717:80,037,111G/A—uncertain significance
rs203394468617:80,037,112G/A—likely benign
rs74705903717:80,037,123C/T—uncertain significance
rs99294605817:80,037,124G/A—likely benign
rs114062317:80,037,129C/T—uncertain significance
rs114062217:80,037,130G/A—likely benign
rs75906177017:80,037,135C/T—uncertain significance
rs118405874817:80,037,147C/G—uncertain significance
rs14441315117:80,037,148G/A—likely benign
rs14659715717:80,037,151G/A—likely benign
rs76007084117:80,037,156C/T—uncertain significance
rs133614770817:80,037,163G/A—likely benign
rs76610301017:80,037,164G/T—likely benign
rs75338046417:80,037,169C/T—likely benign
rs75484767917:80,037,170G/C—likely benign
rs4128336117:80,037,214C/T—likely benign
rs77030490717:80,037,225T/C—likely benign
rs36951602217:80,037,229G/C—uncertain significance
rs37285118417:80,037,251C/T—likely benign
rs14922467917:80,037,253C/T—conflicting classifications of pathogenicity
rs203394776517:80,037,263C/G—uncertain significance
rs75639484317:80,037,265C/T—uncertain significance
rs36916589617:80,037,266G/A—uncertain significance
rs14340776517:80,037,269G/A—benign
rs76885189217:80,037,272G/T—likely benign
rs14837288617:80,037,274C/T—conflicting classifications of pathogenicity
rs37346179617:80,037,275G/A—likely benign
rs130094703317:80,037,281C/T—likely benign
rs77635141017:80,037,282G/A—uncertain significance
rs20182296917:80,037,289C/T—uncertain significance
rs37280780217:80,037,290G/A—likely benign
rs76171551717:80,037,299C/T—uncertain significance
rs75054165217:80,037,304C/T—uncertain significance
rs76990288617:80,037,305G/A—likely benign
rs124993247817:80,037,306T/C—uncertain significance
rs141734896217:80,037,308G/A—likely benign
rs75401633717:80,037,321G/A—uncertain significance
rs75537239217:80,037,330G/A—uncertain significance
rs56549479817:80,037,344G/A—likely benign
rs74539705017:80,037,348C/T—uncertain significance
rs76939184317:80,037,349G/A—uncertain significance
rs20102777817:80,037,362G/T—uncertain significance
rs76834214217:80,037,365G/A—likely benign
rs14013997317:80,037,369C/T—uncertain significance
rs76749224817:80,037,370G/A—uncertain significance
rs214477760917:80,037,372G/A—uncertain significance
rs124709912817:80,037,374C/G—likely benign
rs36934117017:80,037,375G/A—uncertain significance
rs131235793417:80,037,381C/T—uncertain significance
rs250982570517:80,037,382T/G—uncertain significance
rs76077421317:80,037,386C/T—likely benign
rs203395004817:80,037,387T/C—uncertain significance
rs55705012617:80,037,393C/T—uncertain significance
rs76546996617:80,037,394G/A—uncertain significance
rs37361309617:80,037,402C/T—uncertain significance
rs77845808917:80,037,409G/A—uncertain significance
rs133143325717:80,037,412T/A—uncertain significance
rs74745486117:80,037,418T/C—uncertain significance
rs250982580117:80,037,427C/T—uncertain significance
rs121374411817:80,037,428C/T—likely benign
rs74882797017:80,037,429A/G—uncertain significance
rs87912096417:80,037,433C/T—uncertain significance
rs14691869317:80,037,434G/A—likely benign
rs120235270917:80,037,435G/C—uncertain significance
rs20084235217:80,037,439C/A—benign
rs74791523017:80,037,440C/T—likely benign
rs250982583217:80,037,442C/G—uncertain significance
rs203395141117:80,037,449C/T—likely benign
rs13802121017:80,037,462A/C—benign
rs14348506617:80,037,464C/T—benign
rs214477785017:80,037,467C/A—likely benign
rs19978154817:80,037,473C/T—likely benign
rs55734141417:80,037,474G/A—benign
rs136372603617:80,037,482C/A—likely benign
rs76449733917:80,037,483A/G—uncertain significance
rs203395235717:80,037,487G/A—uncertain significance
rs37282623417:80,037,494C/T—likely benign
rs37717689317:80,037,495G/A—likely benign
rs250982593617:80,037,498C/T—likely benign
rs76440947717:80,037,998G/A—likely benign
rs214477875417:80,038,003G/A—likely benign
rs92583677017:80,038,017C/G—uncertain significance
rs77842489717:80,038,027C/G—uncertain significance
rs250982668817:80,038,028C/T—uncertain significance
rs56184404617:80,038,034C/T—likely benign
rs77737058217:80,038,035G/A—uncertain significance
rs74683175717:80,038,037G/A—likely benign
rs13885418117:80,038,049G/A—likely benign
rs203396183017:80,038,058T/C—uncertain significance

Showing 100 of 1,922 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.