FCAR
Fc alpha receptor
Summary
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11666065 | 19:55,384,302 | A/T | — | — |
| rs2066033718 | 19:55,386,795 | T/C | — | uncertain significance |
| rs73065472 | 19:55,389,032 | C/T | intron variant | — |
| rs56216868 | 19:55,389,911 | C/T | intron variant | — |
| rs181695385 | 19:55,390,046 | T/C | intron variant | — |
| rs4806607 | 19:55,395,545 | C/T | regulatory region variant | — |
| rs1024760327 | 19:55,396,651 | C/A | — | uncertain significance |
| rs1226687012 | 19:55,396,709 | G/C | — | uncertain significance |
| rs2066656227 | 19:55,396,826 | G/C | — | uncertain significance |
| rs369048431 | 19:55,396,835 | A/G | — | uncertain significance |
| rs761292534 | 19:55,396,838 | G/A | — | uncertain significance |
| rs766191819 | 19:55,396,851 | C/T | — | uncertain significance |
| rs191759522 | 19:55,396,866 | G/A | — | uncertain significance |
| rs2515303691 | 19:55,396,886 | A/G | — | uncertain significance |
| rs587603137 | 19:55,396,901 | T/A | — | uncertain significance |
| rs2515306073 | 19:55,396,926 | T/A | — | uncertain significance |
| rs149766356 | 19:55,398,311 | C/T | upstream gene variant | — |
| rs371148578 | 19:55,399,383 | G/T | — | uncertain significance |
| rs201648976 | 19:55,399,406 | C/T | — | uncertain significance |
| rs1235954857 | 19:55,399,506 | C/T | — | uncertain significance |
| rs2515363913 | 19:55,399,575 | C/T | — | uncertain significance |
| rs375603668 | 19:55,401,036 | C/T | — | uncertain significance |
| rs747338635 | 19:55,401,053 | C/T | — | uncertain significance |
| rs373544789 | 19:55,401,054 | G/T | — | uncertain significance |
| rs769096695 | 19:55,401,080 | G/A | — | uncertain significance |
| rs377472257 | 19:55,401,098 | C/G | — | uncertain significance |
| rs769204676 | 19:55,401,132 | A/G | — | uncertain significance |
| rs375614240 | 19:55,401,169 | G/T | — | uncertain significance |
| rs769616486 | 19:55,401,207 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.