FENDRR
FOXF1 adjacent non-coding developmental regulatory RNA
Summary
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Known Variants3 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7187365 | 16:86,511,915 | T/A | — | — |
| rs191900668 | 16:86,512,039 | C/A | intron variant | — |
| rs185298574 | 16:86,535,885 | C/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.