FGF21
fibroblast growth factor 21
Summary
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs140856933 | 19:49,259,502 | G/A | — | likely benign |
| rs41308770 | 19:49,259,505 | C/T | — | benign |
| rs551483904 | 19:49,259,626 | C/T | — | uncertain significance |
| rs531768367 | 19:49,259,632 | C/T | — | uncertain significance |
| rs1231357114 | 19:49,259,638 | C/A | — | uncertain significance |
| rs368331867 | 19:49,259,678 | A/C | — | uncertain significance |
| rs773104317 | 19:49,259,689 | G/A | — | uncertain significance |
| rs202109871 | 19:49,259,707 | G/A | — | uncertain significance |
| rs141977654 | 19:49,260,210 | C/T | — | uncertain significance |
| rs2514058014 | 19:49,260,224 | A/G | — | uncertain significance |
| rs150697022 | 19:49,260,250 | C/G | — | uncertain significance |
| rs139679302 | 19:49,260,261 | G/A | — | uncertain significance |
| rs763483884 | 19:49,260,285 | C/G | — | uncertain significance |
| rs142980324 | 19:49,261,218 | G/A | — | uncertain significance |
| rs2514059944 | 19:49,261,241 | T/C | — | uncertain significance |
| rs144978172 | 19:49,261,271 | C/G | — | uncertain significance |
| rs199499120 | 19:49,261,291 | G/T | — | likely benign |
| rs371046094 | 19:49,261,311 | A/T | — | uncertain significance |
| rs780439354 | 19:49,261,319 | C/G | — | uncertain significance |
| rs1401959279 | 19:49,261,334 | C/T | — | uncertain significance |
| rs559156552 | 19:49,261,355 | C/G | — | uncertain significance |
| rs752583057 | 19:49,261,359 | C/A | — | uncertain significance |
| rs376996120 | 19:49,261,364 | G/C | — | uncertain significance |
| rs775377031 | 19:49,261,392 | C/T | — | uncertain significance |
| rs933317607 | 19:49,261,431 | G/A | — | uncertain significance |
| rs202104197 | 19:49,261,455 | G/A | — | uncertain significance |
| rs838130 | 19:49,261,468 | C/T | — | benign |
| rs3745706 | 19:49,261,638 | C/T | downstream gene variant | — |
| rs11665896 | 19:49,261,683 | G/A | — | — |
| rs11665841 | 19:49,261,701 | C/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.