FGL1
fibrinogen like 1
Summary
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Known Variants43 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs768406306 | 8:17,722,123 | T/C | — | uncertain significance |
| rs766847117 | 8:17,722,141 | A/G | — | uncertain significance |
| rs147835809 | 8:17,722,175 | G/A | — | uncertain significance |
| rs372970312 | 8:17,722,226 | T/C | — | uncertain significance |
| rs2517331 | 8:17,722,387 | T/A | — | — |
| rs7818801 | 8:17,722,867 | G/C | downstream gene variant | — |
| rs375736879 | 8:17,726,101 | T/G | — | likely benign |
| rs962996174 | 8:17,726,110 | G/T | — | uncertain significance |
| rs563271358 | 8:17,726,126 | C/G | — | uncertain significance |
| rs766441269 | 8:17,726,168 | A/C | — | uncertain significance |
| rs766665979 | 8:17,726,189 | G/A | — | uncertain significance |
| rs199506227 | 8:17,726,202 | C/T | — | uncertain significance |
| rs765692505 | 8:17,726,466 | G/A | — | uncertain significance |
| rs1386844993 | 8:17,726,490 | G/A | — | uncertain significance |
| rs374685173 | 8:17,731,549 | G/C | — | uncertain significance |
| rs781234321 | 8:17,731,565 | C/A | — | uncertain significance |
| rs35431851 | 8:17,731,611 | T/A | — | benign |
| rs2053406715 | 8:17,731,615 | C/T | — | uncertain significance |
| rs34871936 | 8:17,731,876 | G/A | — | benign |
| rs768389622 | 8:17,731,898 | C/T | — | uncertain significance |
| rs533463660 | 8:17,731,911 | C/T | — | uncertain significance |
| rs34239530 | 8:17,731,914 | T/A | — | conflicting classifications of pathogenicity |
| rs142975385 | 8:17,731,929 | C/T | — | uncertain significance |
| rs776043475 | 8:17,732,016 | A/G | — | uncertain significance |
| rs7843715 | 8:17,733,526 | C/A | intron variant | — |
| rs118004262 | 8:17,736,180 | C/A | upstream gene variant | — |
| rs7815429 | 8:17,737,357 | T/A | — | — |
| rs1205635633 | 8:17,739,555 | C/G | — | uncertain significance |
| rs1206048544 | 8:17,739,564 | A/C | — | uncertain significance |
| rs2487042093 | 8:17,739,576 | T/A | — | uncertain significance |
| rs1430064702 | 8:17,739,601 | T/C | — | uncertain significance |
| rs139324987 | 8:17,739,624 | C/T | — | benign |
| rs761457705 | 8:17,739,634 | G/A | — | uncertain significance |
| rs758161799 | 8:17,739,640 | G/C | — | uncertain significance |
| rs746437329 | 8:17,739,659 | C/T | — | uncertain significance |
| rs149986161 | 8:17,739,672 | G/T | — | uncertain significance |
| rs143971989 | 8:17,739,676 | A/C | — | uncertain significance |
| rs199806000 | 8:17,739,687 | G/A | — | uncertain significance |
| rs34019488 | 8:17,739,691 | G/C | — | likely benign |
| rs61745168 | 8:17,743,030 | T/C | — | uncertain significance |
| rs2073566 | 8:17,743,655 | G/T | — | — |
| rs10099622 | 8:17,743,994 | C/T | downstream gene variant | — |
| rs17634704 | 8:17,753,306 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.