FMO4
flavin containing dimethylaniline monoxygenase 4
Summary
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Known Variants37 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs60906481 | 1:171,289,025 | T/C | — | uncertain significance |
| rs1473133232 | 1:171,289,033 | T/G | — | uncertain significance |
| rs866374389 | 1:171,289,047 | C/A | — | uncertain significance |
| rs150752522 | 1:171,289,076 | G/C | — | uncertain significance |
| rs2525971584 | 1:171,292,198 | G/T | — | uncertain significance |
| rs1183429707 | 1:171,292,254 | A/T | — | uncertain significance |
| rs2525972857 | 1:171,292,324 | A/T | — | uncertain significance |
| rs746984414 | 1:171,293,278 | C/T | — | uncertain significance |
| rs781342399 | 1:171,293,288 | C/G | — | uncertain significance |
| rs770117618 | 1:171,293,296 | C/T | — | uncertain significance |
| rs368144728 | 1:171,293,320 | C/T | — | uncertain significance |
| rs767244751 | 1:171,300,850 | C/T | — | uncertain significance |
| rs200809129 | 1:171,300,853 | G/A | — | likely benign |
| rs138259447 | 1:171,300,908 | G/A | — | uncertain significance |
| rs61747501 | 1:171,301,882 | T/A | — | likely benign |
| rs376908107 | 1:171,301,885 | G/C | — | uncertain significance |
| rs2526024364 | 1:171,301,894 | C/T | — | uncertain significance |
| rs1268871901 | 1:171,302,040 | A/T | — | uncertain significance |
| rs1011072210 | 1:171,303,563 | T/C | — | uncertain significance |
| rs3737926 | 1:171,303,565 | C/T | — | benign |
| rs769736989 | 1:171,303,575 | G/A | — | uncertain significance |
| rs756978964 | 1:171,303,625 | C/A | — | uncertain significance |
| rs756951706 | 1:171,303,677 | G/A | — | uncertain significance |
| rs749983842 | 1:171,303,797 | A/T | — | uncertain significance |
| rs45599742 | 1:171,303,836 | G/A | — | likely benign |
| rs1011605442 | 1:171,303,860 | G/A | — | uncertain significance |
| rs369013232 | 1:171,303,905 | A/G | — | uncertain significance |
| rs45445497 | 1:171,306,520 | A/G | — | benign |
| rs74607987 | 1:171,310,562 | A/C | — | likely benign |
| rs762531063 | 1:171,310,602 | T/C | — | uncertain significance |
| rs779547888 | 1:171,310,680 | A/C | — | uncertain significance |
| rs2526074254 | 1:171,310,718 | C/T | — | uncertain significance |
| rs143713856 | 1:171,310,775 | A/G | — | uncertain significance |
| rs758709702 | 1:171,310,779 | C/T | — | uncertain significance |
| rs963535946 | 1:171,310,839 | A/G | — | uncertain significance |
| rs75661671 | 1:171,310,901 | T/C | — | benign |
| rs200262164 | 1:171,310,959 | T/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.