FNIP1

folliculin interacting protein 1

Summary

This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

Known Variants297 total

rsidPosition (GRCh37)AllelesClassClinVar
rs25320831455:130,980,457C/A—uncertain significance
rs10202662285:130,980,464A/G—likely benign
rs7724638585:130,980,471A/G—likely benign
rs260065:130,982,768A/G—benign
rs11974058735:130,982,816C/T—uncertain significance
rs7796250915:130,982,824C/A—likely benign
rs21495015515:130,982,852C/T—pathogenic
rs3714795805:130,982,888T/C—uncertain significance
rs3747840195:130,982,912G/A—likely benign
rs7783007335:130,987,478G/A—likely benign
rs7473374275:130,987,487A/G—likely benign
rs21495040535:130,987,494C/T—pathogenic
rs783677765:130,987,503G/A—uncertain significance
rs14909263835:130,987,512T/C—uncertain significance
rs9147443355:130,987,559C/A—uncertain significance
rs7463713565:130,987,569A/G—likely benign
rs7652928385:130,987,589T/C—uncertain significance
rs1386672825:130,987,601C/T—uncertain significance
rs17670505635:130,987,610C/G—uncertain significance
rs3712646685:130,987,649A/G—uncertain significance
rs1436823855:130,987,666T/C—likely benign
rs8910435245:130,987,697A/G—likely benign
rs274505:131,006,082A/G—benign
rs25321228285:131,006,137A/G—likely benign
rs7493409565:131,006,166T/C—uncertain significance
rs1838609075:131,006,171T/C—likely benign
rs7483789945:131,006,176C/G—uncertain significance
rs1439214155:131,006,194G/A—uncertain significance
rs25321229885:131,006,213A/G—likely benign
rs7511518965:131,006,240A/G—likely benign
rs7686514365:131,006,249G/A—likely benign
rs1152902015:131,006,273C/T—benign
rs7527316025:131,006,276G/A—likely benign
rs13368476645:131,006,291G/A—likely benign
rs12184821355:131,006,339C/T—likely benign
rs25321233225:131,006,340C/T—likely benign
rs260075:131,006,356T/A—benign
rs1391178515:131,007,226C/A—benign
rs25321253545:131,007,238G/T—uncertain significance
rs1432453605:131,007,268T/C—uncertain significance
rs1508746545:131,007,282C/A—uncertain significance
rs25321254765:131,007,287A/G—likely benign
rs3740863145:131,007,340T/G—uncertain significance
rs25321256045:131,007,347T/C—likely benign
rs7815088245:131,007,351G/C—uncertain significance
rs762249535:131,007,358C/T—benign
rs1496277895:131,007,398G/T—likely benign
rs25321259035:131,007,413T/C—likely benign
rs25321259205:131,007,416A/G—likely benign
rs1444481225:131,007,425G/C—likely benign
rs1440572525:131,007,440G/A—likely benign
rs14155027555:131,007,469T/C—uncertain significance
rs7635475905:131,007,477C/T—uncertain significance
rs617466005:131,007,487A/G—benign
rs25321261425:131,007,488T/A—uncertain significance
rs7677035595:131,007,491A/C—uncertain significance
rs7563507525:131,007,507T/C—uncertain significance
rs11849383165:131,007,540A/G—uncertain significance
rs7805705275:131,007,553C/T—uncertain significance
rs17677631725:131,007,554T/C—likely benign
rs12762278705:131,007,593A/C—likely benign
rs3775901435:131,007,604C/T—uncertain significance
rs1398574355:131,007,605G/T—likely benign
rs77178745:131,007,607T/C—benign
rs9227295105:131,007,617A/G—likely benign
rs9172059895:131,007,629G/A—likely benign
rs3731916195:131,007,632G/A—likely benign
rs7650752375:131,007,660T/C—uncertain significance
rs12020202185:131,007,672G/A—uncertain significance
rs7526353505:131,007,693G/A—uncertain significance
rs5683524355:131,007,701G/A—likely benign
rs121089545:131,007,710A/G—benign
rs7511098615:131,007,715A/C—uncertain significance
rs1467853675:131,007,725T/C—likely benign
rs17677704145:131,007,734G/C—likely benign
rs13521397055:131,007,747G/A—uncertain significance
rs7726713505:131,007,752T/C—likely benign
rs3733287015:131,007,765A/G—uncertain significance
rs3741002255:131,007,770C/T—likely benign
rs7597345785:131,007,771C/T—uncertain significance
rs17677728565:131,007,781C/T—uncertain significance
rs775544425:131,007,787A/G—benign
rs25321269245:131,007,812C/G—uncertain significance
rs7485597685:131,007,855G/A—uncertain significance
rs1995921465:131,007,863A/G—likely benign
rs25321270875:131,007,873A/G—uncertain significance
rs13301154415:131,007,902C/T—likely benign
rs121097825:131,007,925C/A—likely benign
rs7706321165:131,007,927A/G—uncertain significance
rs12804298825:131,007,928T/C—uncertain significance
rs17677808245:131,007,946T/G—uncertain significance
rs1855581645:131,007,948T/C—likely benign
rs17677813575:131,007,959T/C—likely benign
rs1463382475:131,007,963G/A—uncertain significance
rs7697499605:131,008,022T/G—likely benign
rs7757576705:131,008,032G/A—uncertain significance
rs7684555745:131,008,038T/C—uncertain significance
rs1391815885:131,008,039C/G—likely benign
rs3686948605:131,008,073T/C—likely benign
rs2014949795:131,008,086G/A—uncertain significance

Showing 100 of 297 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.