FNIP2
folliculin interacting protein 2
Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Known Variants70 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs769245388 | 4:159,690,429 | C/T | — | uncertain significance |
| rs11933662 | 4:159,705,840 | G/T | — | — |
| rs4130344 | 4:159,726,345 | T/C | — | — |
| rs781083346 | 4:159,747,072 | T/C | — | uncertain significance |
| rs2477221798 | 4:159,753,026 | C/T | — | uncertain significance |
| rs2477239368 | 4:159,754,759 | T/C | — | uncertain significance |
| rs535927444 | 4:159,772,530 | C/G | — | uncertain significance |
| rs7663520 | 4:159,777,764 | A/G | — | — |
| rs200960984 | 4:159,780,242 | A/T | — | uncertain significance |
| rs1421485667 | 4:159,780,292 | G/A | — | uncertain significance |
| rs2477476750 | 4:159,780,345 | T/G | — | uncertain significance |
| rs368406944 | 4:159,780,346 | T/A | — | uncertain significance |
| rs967358022 | 4:159,780,388 | G/A | — | uncertain significance |
| rs199995620 | 4:159,780,791 | G/A | — | uncertain significance |
| rs373204875 | 4:159,782,513 | T/C | — | uncertain significance |
| rs200154804 | 4:159,782,600 | A/G | — | uncertain significance |
| rs201676571 | 4:159,782,620 | A/G | — | uncertain significance |
| rs1031205703 | 4:159,782,782 | C/T | — | uncertain significance |
| rs765081062 | 4:159,782,814 | A/G | — | uncertain significance |
| rs778087047 | 4:159,782,865 | A/G | — | uncertain significance |
| rs75305192 | 4:159,789,264 | C/T | — | benign |
| rs532436555 | 4:159,789,307 | G/A | — | uncertain significance |
| rs183843185 | 4:159,789,319 | A/G | — | uncertain significance |
| rs147318337 | 4:159,789,403 | G/C | — | benign |
| rs538008197 | 4:159,789,413 | G/C | — | uncertain significance |
| rs372920721 | 4:159,789,500 | C/T | — | uncertain significance |
| rs73858598 | 4:159,789,501 | G/A | — | likely benign |
| rs760450033 | 4:159,789,520 | C/G | — | uncertain significance |
| rs1259799193 | 4:159,789,542 | C/A | — | uncertain significance |
| rs200484810 | 4:159,789,610 | A/G | — | uncertain significance |
| rs201778719 | 4:159,789,679 | G/A | — | likely benign |
| rs368062140 | 4:159,789,681 | A/G | — | likely benign |
| rs199556655 | 4:159,789,686 | G/T | — | likely benign |
| rs1315857316 | 4:159,789,706 | G/A | — | uncertain significance |
| rs374889035 | 4:159,789,758 | C/G | — | uncertain significance |
| rs375452697 | 4:159,789,802 | G/A | — | uncertain significance |
| rs371963974 | 4:159,789,827 | A/G | — | uncertain significance |
| rs201095537 | 4:159,789,850 | G/A | — | uncertain significance |
| rs754947611 | 4:159,789,858 | G/A | — | uncertain significance |
| rs375103955 | 4:159,789,877 | C/T | — | uncertain significance |
| rs868510392 | 4:159,789,913 | C/T | — | likely benign |
| rs369087052 | 4:159,789,914 | G/A | — | uncertain significance |
| rs761676307 | 4:159,789,989 | G/A | — | uncertain significance |
| rs552221687 | 4:159,790,001 | T/C | — | uncertain significance |
| rs756934778 | 4:159,790,008 | A/T | — | uncertain significance |
| rs62001913 | 4:159,790,010 | A/G | — | likely benign |
| rs568209548 | 4:159,790,112 | A/G | — | uncertain significance |
| rs778657615 | 4:159,790,132 | C/T | — | uncertain significance |
| rs769165542 | 4:159,790,156 | G/A | — | uncertain significance |
| rs201629749 | 4:159,790,159 | T/A | — | uncertain significance |
| rs759628077 | 4:159,790,201 | A/G | — | likely benign |
| rs780723819 | 4:159,790,237 | G/A | — | uncertain significance |
| rs200457167 | 4:159,790,253 | C/T | — | uncertain significance |
| rs1780775542 | 4:159,790,328 | G/A | — | uncertain significance |
| rs773094499 | 4:159,790,372 | C/T | — | likely benign |
| rs759181083 | 4:159,790,381 | G/A | — | uncertain significance |
| rs2477578536 | 4:159,790,418 | A/G | — | likely benign |
| rs767344275 | 4:159,790,556 | T/C | — | uncertain significance |
| rs756311041 | 4:159,791,505 | C/T | — | uncertain significance |
| rs13148521 | 4:159,802,111 | A/G | intron variant | — |
| rs4691521 | 4:159,802,373 | G/A | intron variant | — |
| rs182433817 | 4:159,803,345 | C/A | — | — |
| rs149170475 | 4:159,803,349 | C/G | intron variant | — |
| rs149229477 | 4:159,812,339 | C/T | — | — |
| rs200009550 | 4:159,812,658 | T/C | — | uncertain significance |
| rs750524346 | 4:159,812,695 | C/T | — | likely benign |
| rs368022045 | 4:159,812,703 | A/G | — | uncertain significance |
| rs747432492 | 4:159,812,745 | A/G | — | uncertain significance |
| rs768943544 | 4:159,812,760 | A/G | — | uncertain significance |
| rs202019221 | 4:159,816,935 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.