FOSL1
FOS like 1, AP-1 transcription factor subunit
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs759043572 | 11:65,660,377 | G/C | — | uncertain significance |
| rs142119979 | 11:65,660,378 | A/G | — | benign |
| rs141976219 | 11:65,660,490 | G/T | — | uncertain significance |
| rs144760068 | 11:65,660,600 | G/T | — | benign |
| rs114787843 | 11:65,660,648 | C/T | — | benign |
| rs750196473 | 11:65,660,748 | T/A | — | uncertain significance |
| rs368497099 | 11:65,661,564 | C/A | — | uncertain significance |
| rs58568715 | 11:65,662,985 | A/G | downstream gene variant | — |
| rs201410689 | 11:65,664,299 | C/A | — | uncertain significance |
| rs758410472 | 11:65,664,350 | G/T | — | uncertain significance |
| rs1304050057 | 11:65,664,383 | G/A | — | uncertain significance |
| rs1321931685 | 11:65,664,392 | C/A | — | uncertain significance |
| rs991654454 | 11:65,664,396 | G/T | — | uncertain significance |
| rs368840880 | 11:65,664,408 | G/A | — | uncertain significance |
| rs1457961074 | 11:65,664,461 | G/C | — | uncertain significance |
| rs757312993 | 11:65,664,476 | T/C | — | uncertain significance |
| rs634534 | 11:65,665,256 | A/C | — | — |
| rs689274 | 11:65,665,988 | A/G | regulatory region variant | — |
| rs941921723 | 11:65,667,798 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.