FST
follistatin
Summary
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs62370480 | 5:52,774,510 | G/A | regulatory region variant | — |
| rs773779294 | 5:52,776,638 | A/C | — | uncertain significance |
| rs150238035 | 5:52,776,673 | C/T | — | benign |
| rs181213082 | 5:52,776,715 | G/C | — | benign |
| rs55744247 | 5:52,777,864 | G/A | regulatory region variant | — |
| rs1747328996 | 5:52,778,791 | G/A | — | conflicting classifications of pathogenicity |
| rs781612641 | 5:52,779,411 | G/A | — | uncertain significance |
| rs11745088 | 5:52,779,510 | G/C | — | benign |
| rs150492112 | 5:52,779,983 | G/A | — | benign |
| rs12152850 | 5:52,780,353 | C/T | intron variant | — |
| rs748145800 | 5:52,780,902 | G/A | — | uncertain significance |
| rs2478439191 | 5:52,780,947 | A/G | — | uncertain significance |
| rs142670747 | 5:52,780,949 | C/G | — | uncertain significance |
| rs1416496638 | 5:52,780,952 | G/C | — | uncertain significance |
| rs781168844 | 5:52,781,011 | C/T | — | likely benign |
| rs722910 | 5:52,781,597 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.