FUS

FUS RNA binding protein

Summary

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Known Variants427 total

rsidPosition (GRCh37)AllelesClassClinVar
rs988885116:31,191,372C/T—likely benign
rs76301006916:31,191,418G/A—uncertain significance
rs92986716:31,191,482A/Gregulatory region variantbenign
rs75966825616:31,191,483C/T—uncertain significance
rs57169600316:31,191,485C/T—uncertain significance
rs20099707516:31,191,487G/T—uncertain significance
rs19967174316:31,191,488C/G—uncertain significance
rs7255086416:31,191,489G/A—likely benign
rs37032090916:31,191,492G/A—likely benign
rs6767635616:31,191,497A/G—likely benign
rs76847742816:31,191,521C/G—uncertain significance
rs74805055416:31,191,530G/C—uncertain significance
rs77317288116:31,191,531C/G—likely benign
rs54967113016:31,191,541C/T—likely benign
rs57130234416:31,191,987G/C——
rs19986774016:31,193,710C/G—likely benign
rs75023072216:31,193,736A/G—uncertain significance
rs77175442516:31,193,762C/T—likely benign
rs254424723316:31,193,816G/A—uncertain significance
rs116292013716:31,193,822C/T—uncertain significance
rs144924308116:31,193,823C/G—likely benign
rs207919458716:31,193,835T/A—uncertain significance
rs75807387716:31,193,836A/G—uncertain significance
rs13998026716:31,193,842C/T—likely benign
rs14488813816:31,193,847C/T—uncertain significance
rs14787761316:31,193,861G/A—likely benign
rs14151641416:31,193,869A/C—uncertain significance
rs148537797616:31,193,885T/C—likely benign
rs131686052516:31,193,890C/T—uncertain significance
rs93253410216:31,193,891C/T—likely benign
rs37150366316:31,193,894C/T—likely benign
rs14706662716:31,193,914G/C—likely benign
rs7255088316:31,193,927C/T—likely benign
rs214410178916:31,193,930G/T—likely benign
rs8006043816:31,193,939A/G—likely benign
rs74181016:31,193,942C/Asynonymous variantbenign
rs6173396216:31,193,948C/T—benign
rs75461361916:31,193,956G/A—likely benign
rs159689020116:31,193,959A/G—uncertain significance
rs78088787616:31,193,969T/C—likely benign
rs148106039116:31,193,976A/G—uncertain significance
rs77736521616:31,193,977G/A—uncertain significance
rs14088321116:31,193,983A/G—conflicting classifications of pathogenicity
rs7353028316:31,193,994T/C—benign
rs74743352916:31,194,001C/T—likely benign
rs18546911316:31,194,158C/G—likely benign
rs11295792116:31,194,182T/C—benign
rs18303220416:31,194,201C/T—likely benign
rs11141515116:31,194,226G/A—likely benign
rs14692808016:31,194,236C/T—likely benign
rs13823821916:31,194,246A/C—likely benign
rs20145895216:31,195,138T/C—likely benign
rs14124231116:31,195,156C/G—likely benign
rs77199056916:31,195,169A/G—likely benign
rs74694470916:31,195,171C/T—likely benign
rs146493118816:31,195,178G/A—uncertain significance
rs77633395616:31,195,180A/G—conflicting classifications of pathogenicity
rs14485344716:31,195,186T/C—likely benign
rs76248847516:31,195,199A/G—uncertain significance
rs214410725916:31,195,203C/T—uncertain significance
rs76448784716:31,195,205C/T—likely pathogenic
rs75745459516:31,195,210A/G—conflicting classifications of pathogenicity
rs74609307316:31,195,219G/A—likely benign
rs78003220516:31,195,222T/C—likely benign
rs254425188516:31,195,224G/A—uncertain significance
rs53593092716:31,195,225C/T—benign
rs77647457116:31,195,226G/A—conflicting classifications of pathogenicity
rs254425197216:31,195,241C/T—pathogenic
rs76587119816:31,195,252A/G—likely benign
rs37263866316:31,195,253T/A—uncertain significance
rs76122238216:31,195,255G/A—likely benign
rs7353028616:31,195,261C/T—likely benign
rs76209541816:31,195,273C/G—likely benign
rs105235216:31,195,279C/Tsynonymous variantbenign
rs37642489216:31,195,288T/C—likely benign
rs37419110716:31,195,305C/T—conflicting classifications of pathogenicity
rs20026470916:31,195,306C/T—likely benign
rs138000971616:31,195,329G/C—uncertain significance
rs20182351416:31,195,331G/C—likely benign
rs77389803816:31,195,342C/T—likely benign
rs119283007416:31,195,510T/G—likely benign
rs77061211816:31,195,511T/G—likely benign
rs96704430616:31,195,525C/A—uncertain significance
rs37129898116:31,195,526C/G—likely benign
rs76228730416:31,195,527T/C—uncertain significance
rs77034511816:31,195,533C/T—likely benign
rs18680288916:31,195,534G/A—uncertain significance
rs139849770616:31,195,539C/T—likely benign
rs254425310816:31,195,547A/G—uncertain significance
rs36814847516:31,195,569C/G—likely benign
rs207922581716:31,195,586G/A—uncertain significance
rs88605193416:31,195,597A/G—uncertain significance
rs6173297016:31,195,598G/A—likely benign
rs148790334816:31,195,602T/C—likely benign
rs254425341016:31,195,608A/G—likely benign
rs254425345916:31,195,623T/C—likely benign
rs77952744816:31,195,626A/T—likely benign
rs77365504916:31,195,637G/C—conflicting classifications of pathogenicity
rs14434294616:31,195,646C/T—conflicting classifications of pathogenicity
rs90849941416:31,195,647C/T—likely benign

Showing 100 of 427 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.