FYB1
FYN binding protein 1
Summary
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Known Variants121 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs358501 | 5:39,105,594 | C/T | downstream gene variant | — |
| rs2161612 | 5:39,107,100 | A/G | downstream gene variant | — |
| rs404122 | 5:39,107,353 | T/A | — | benign |
| rs759776144 | 5:39,107,553 | T/A | — | uncertain significance |
| rs763195960 | 5:39,107,567 | C/T | — | uncertain significance |
| rs382753 | 5:39,107,883 | A/G | — | benign |
| rs377022 | 5:39,108,309 | A/G | — | benign |
| rs430630 | 5:39,108,322 | A/G | — | benign |
| rs2546948763 | 5:39,108,345 | C/T | — | uncertain significance |
| rs77289629 | 5:39,110,414 | A/T | — | benign |
| rs1047993806 | 5:39,110,459 | T/G | — | uncertain significance |
| rs757096001 | 5:39,110,481 | G/A | — | likely benign |
| rs1054969715 | 5:39,118,988 | C/T | — | uncertain significance |
| rs766332361 | 5:39,119,003 | C/A | — | uncertain significance |
| rs779141473 | 5:39,119,020 | G/A | — | uncertain significance |
| rs141054334 | 5:39,119,027 | T/A | — | uncertain significance |
| rs527371096 | 5:39,119,083 | G/A | — | uncertain significance |
| rs537957797 | 5:39,119,087 | T/C | — | uncertain significance |
| rs427829 | 5:39,119,222 | G/T | — | benign |
| rs16868122 | 5:39,119,244 | A/G | — | benign |
| rs394930 | 5:39,119,561 | C/T | — | benign |
| rs379707 | 5:39,119,723 | C/A | missense variant | benign |
| rs2546977351 | 5:39,122,440 | C/A | — | uncertain significance |
| rs762151772 | 5:39,122,501 | A/G | — | uncertain significance |
| rs778885656 | 5:39,124,358 | A/G | — | likely benign |
| rs2303807 | 5:39,124,508 | C/T | — | benign |
| rs2303806 | 5:39,124,593 | A/T | — | benign |
| rs4957132 | 5:39,125,799 | G/C | — | benign |
| rs199924788 | 5:39,126,145 | C/T | — | conflicting classifications of pathogenicity |
| rs1189366110 | 5:39,126,186 | C/G | — | uncertain significance |
| rs75710164 | 5:39,126,204 | C/T | — | likely benign |
| rs552390836 | 5:39,126,217 | T/C | — | uncertain significance |
| rs199923708 | 5:39,126,223 | A/G | — | conflicting classifications of pathogenicity |
| rs114690770 | 5:39,126,557 | G/T | — | benign |
| rs77912788 | 5:39,127,703 | C/T | — | benign |
| rs138071153 | 5:39,127,844 | C/A | — | likely benign |
| rs56166211 | 5:39,127,960 | G/C | — | benign |
| rs7724541 | 5:39,133,985 | T/G | — | benign |
| rs7704365 | 5:39,134,019 | A/G | — | benign |
| rs68032871 | 5:39,134,169 | T/C | — | benign |
| rs4957318 | 5:39,134,295 | C/T | — | benign |
| rs78841904 | 5:39,134,417 | A/G | — | benign |
| rs2303805 | 5:39,134,602 | A/C | — | benign |
| rs6868792 | 5:39,134,735 | C/T | — | benign |
| rs1433662166 | 5:39,134,963 | C/T | — | uncertain significance |
| rs752902614 | 5:39,134,981 | A/G | — | likely benign |
| rs758703264 | 5:39,135,001 | T/C | — | uncertain significance |
| rs1053335485 | 5:39,135,003 | T/C | — | likely benign |
| rs2547012285 | 5:39,135,073 | C/T | — | uncertain significance |
| rs752002051 | 5:39,135,104 | T/A | — | uncertain significance |
| rs754545241 | 5:39,135,121 | A/G | — | likely benign |
| rs6451413 | 5:39,137,380 | A/G | — | benign |
| rs2547019182 | 5:39,137,820 | T/C | — | uncertain significance |
| rs2303804 | 5:39,137,966 | G/A | — | benign |
| rs7712715 | 5:39,138,534 | T/C | — | benign |
| rs10052923 | 5:39,139,135 | T/A | — | benign |
| rs10059957 | 5:39,139,176 | A/G | — | benign |
| rs960548060 | 5:39,139,352 | C/A | — | uncertain significance |
| rs56278914 | 5:39,139,665 | A/G | — | benign |
| rs10214021 | 5:39,141,088 | A/G | — | benign |
| rs759487838 | 5:39,141,232 | T/C | — | uncertain significance |
| rs3188386 | 5:39,141,240 | G/A | — | benign |
| rs66657445 | 5:39,141,521 | T/A | — | benign |
| rs6861690 | 5:39,153,251 | G/T | — | benign |
| rs41302832 | 5:39,153,529 | A/G | — | benign |
| rs115158663 | 5:39,153,561 | C/T | — | likely benign |
| rs199876614 | 5:39,153,562 | G/A | — | likely benign |
| rs751617975 | 5:39,153,583 | G/A | — | uncertain significance |
| rs2547072021 | 5:39,153,652 | G/C | — | uncertain significance |
| rs762792496 | 5:39,153,688 | G/A | — | uncertain significance |
| rs2547072260 | 5:39,153,690 | C/G | — | uncertain significance |
| rs7717006 | 5:39,153,881 | G/A | — | benign |
| rs181079388 | 5:39,195,610 | T/G | regulatory region variant | — |
| rs3749740 | 5:39,201,899 | A/G | — | benign |
| rs75715521 | 5:39,201,920 | G/T | — | likely benign |
| rs369776115 | 5:39,201,946 | T/C | — | uncertain significance |
| rs201436179 | 5:39,201,957 | G/C | — | uncertain significance |
| rs370543746 | 5:39,201,980 | G/C | — | uncertain significance |
| rs780303540 | 5:39,202,013 | C/A | — | uncertain significance |
| rs959005444 | 5:39,202,041 | G/T | — | uncertain significance |
| rs3749741 | 5:39,202,068 | T/C | — | benign |
| rs74512678 | 5:39,202,081 | G/T | — | benign |
| rs2478401734 | 5:39,202,102 | T/C | — | uncertain significance |
| rs775511693 | 5:39,202,114 | G/C | — | uncertain significance |
| rs201570574 | 5:39,202,118 | C/A | — | uncertain significance |
| rs2478402542 | 5:39,202,120 | T/C | — | uncertain significance |
| rs2478404638 | 5:39,202,177 | G/T | — | uncertain significance |
| rs2478407415 | 5:39,202,240 | G/A | — | uncertain significance |
| rs141281683 | 5:39,202,244 | T/G | — | benign |
| rs61734281 | 5:39,202,249 | C/A | — | uncertain significance |
| rs371334972 | 5:39,202,259 | C/T | — | likely benign |
| rs756052499 | 5:39,202,320 | T/A | — | uncertain significance |
| rs34222014 | 5:39,202,357 | C/T | — | uncertain significance |
| rs747350975 | 5:39,202,378 | G/T | — | uncertain significance |
| rs768216641 | 5:39,202,389 | G/T | — | uncertain significance |
| rs369993453 | 5:39,202,457 | C/T | — | likely benign |
| rs369250314 | 5:39,202,604 | C/T | — | likely benign |
| rs773877131 | 5:39,202,605 | G/C | — | uncertain significance |
| rs536980773 | 5:39,202,640 | A/C | — | uncertain significance |
| rs201568060 | 5:39,202,653 | G/A | — | likely benign |
Showing 100 of 121 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.