GBP3

guanylate binding protein 3

Summary

This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]

Known Variants32 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7485373041:89,473,447T/Auncertain significance
rs1149109771:89,473,453G/Abenign
rs5493806511:89,473,525C/Auncertain significance
rs7731971831:89,474,726A/Tuncertain significance
rs2001799401:89,474,738C/Guncertain significance
rs12902054981:89,474,817C/Tuncertain significance
rs174337801:89,474,818A/Gmissense variant
rs7777664341:89,476,681C/Tuncertain significance
rs5762619421:89,476,788G/Tlikely benign
rs1433330051:89,477,570T/Cuncertain significance
rs1484366351:89,477,606C/Tuncertain significance
rs7531215721:89,477,611G/Auncertain significance
rs1402705321:89,477,619T/Cuncertain significance
rs11885482531:89,477,648C/Tuncertain significance
rs7479813761:89,478,942G/Auncertain significance
rs3697027541:89,478,979C/Guncertain significance
rs3706928001:89,479,011C/Tuncertain significance
rs3751998761:89,479,012G/Alikely benign
rs3735424311:89,479,026T/Cuncertain significance
rs7623455591:89,479,062C/Tlikely benign
rs13982398671:89,479,072G/Auncertain significance
rs14351992801:89,479,793G/Cuncertain significance
rs1435895151:89,480,306G/Cuncertain significance
rs12633313101:89,480,339C/Tuncertain significance
rs25233810931:89,481,083A/Guncertain significance
rs5760280101:89,482,990T/G
rs1485623681:89,486,263G/Auncertain significance
rs7513842991:89,486,274A/Guncertain significance
rs2013582521:89,486,287C/Tuncertain significance
rs16791388241:89,486,358T/Guncertain significance
rs1413159301:89,486,376G/Auncertain significance
rs1908876261:89,487,544G/Aregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.