GCN1
GCN1 activator of EIF2AK4
Summary
Enables several functions, including protein kinase regulator activity; stalled ribosome sensor activity; and ubiquitin-protein transferase regulator activity. Involved in protein-RNA covalent cross-linking repair. Located in cytosol. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants146 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs769464525 | 12:120,565,690 | T/A | — | uncertain significance |
| rs1254584074 | 12:120,565,693 | G/A | — | uncertain significance |
| rs770357732 | 12:120,565,720 | C/T | — | uncertain significance |
| rs773861589 | 12:120,565,723 | C/T | — | uncertain significance |
| rs372483013 | 12:120,567,104 | C/T | — | uncertain significance |
| rs375253959 | 12:120,567,117 | T/C | — | uncertain significance |
| rs548401692 | 12:120,567,133 | C/T | — | uncertain significance |
| rs1418597652 | 12:120,567,168 | G/A | — | uncertain significance |
| rs369470290 | 12:120,568,468 | A/G | — | likely benign |
| rs373248631 | 12:120,568,478 | G/A | — | uncertain significance |
| rs1876789897 | 12:120,568,554 | G/A | — | uncertain significance |
| rs374035797 | 12:120,568,996 | G/A | — | uncertain significance |
| rs199806615 | 12:120,569,044 | C/T | — | uncertain significance |
| rs770877751 | 12:120,569,045 | C/T | — | uncertain significance |
| rs2503812907 | 12:120,569,066 | C/A | — | uncertain significance |
| rs764827741 | 12:120,569,081 | C/T | — | uncertain significance |
| rs772194593 | 12:120,569,122 | A/G | — | uncertain significance |
| rs753797968 | 12:120,569,734 | C/A | — | uncertain significance |
| rs1354666112 | 12:120,572,370 | T/C | — | uncertain significance |
| rs902755398 | 12:120,572,457 | C/A | — | uncertain significance |
| rs748265718 | 12:120,574,332 | C/T | — | uncertain significance |
| rs185701009 | 12:120,574,342 | C/T | — | likely benign |
| rs201840533 | 12:120,574,343 | G/A | — | uncertain significance |
| rs777529738 | 12:120,574,407 | C/T | — | uncertain significance |
| rs1434316893 | 12:120,575,033 | G/C | — | uncertain significance |
| rs2503829748 | 12:120,575,080 | T/G | — | uncertain significance |
| rs777183394 | 12:120,575,379 | C/G | — | uncertain significance |
| rs7135057 | 12:120,575,400 | G/A | — | benign |
| rs1877051735 | 12:120,575,423 | G/C | — | uncertain significance |
| rs1190074359 | 12:120,575,489 | G/A | — | uncertain significance |
| rs187271720 | 12:120,575,531 | G/A | — | uncertain significance |
| rs146550123 | 12:120,575,576 | C/T | — | uncertain significance |
| rs567031059 | 12:120,575,824 | G/A | — | uncertain significance |
| rs913742188 | 12:120,576,150 | C/T | — | uncertain significance |
| rs11065033 | 12:120,576,227 | G/C | — | benign |
| rs369707758 | 12:120,576,549 | T/C | — | uncertain significance |
| rs2503835419 | 12:120,576,609 | C/A | — | uncertain significance |
| rs61733796 | 12:120,576,637 | G/A | — | benign |
| rs1877167823 | 12:120,578,671 | G/A | — | uncertain significance |
| rs7300790 | 12:120,580,323 | T/C | — | benign |
| rs1877229931 | 12:120,580,324 | G/C | — | uncertain significance |
| rs1877232163 | 12:120,580,373 | G/T | — | uncertain significance |
| rs1283511981 | 12:120,580,391 | G/A | — | uncertain significance |
| rs201566795 | 12:120,580,409 | C/T | — | uncertain significance |
| rs189115314 | 12:120,580,432 | G/A | — | uncertain significance |
| rs905321849 | 12:120,580,462 | C/T | — | uncertain significance |
| rs759823249 | 12:120,582,186 | T/C | — | uncertain significance |
| rs760797911 | 12:120,582,197 | C/T | — | uncertain significance |
| rs762924784 | 12:120,582,544 | G/A | — | uncertain significance |
| rs1329097557 | 12:120,582,776 | C/G | — | uncertain significance |
| rs1877385964 | 12:120,584,863 | T/C | — | uncertain significance |
| rs2503858899 | 12:120,584,903 | T/A | — | uncertain significance |
| rs118078431 | 12:120,584,910 | C/T | — | likely benign |
| rs754519237 | 12:120,586,028 | C/A | — | uncertain significance |
| rs768800152 | 12:120,586,112 | G/A | — | uncertain significance |
| rs750993380 | 12:120,587,427 | G/A | — | uncertain significance |
| rs766802566 | 12:120,587,473 | C/A | — | uncertain significance |
| rs1237497949 | 12:120,587,730 | C/A | — | uncertain significance |
| rs373411123 | 12:120,588,961 | G/A | — | uncertain significance |
| rs751330162 | 12:120,589,002 | A/G | — | uncertain significance |
| rs2503871108 | 12:120,589,006 | T/G | — | uncertain significance |
| rs763126095 | 12:120,589,078 | G/A | — | uncertain significance |
| rs756784739 | 12:120,589,134 | C/G | — | uncertain significance |
| rs763412059 | 12:120,589,150 | T/C | — | uncertain significance |
| rs2503877065 | 12:120,591,019 | G/T | — | uncertain significance |
| rs750094629 | 12:120,591,156 | T/C | — | uncertain significance |
| rs200124782 | 12:120,591,201 | T/C | — | uncertain significance |
| rs763439791 | 12:120,592,840 | G/A | — | uncertain significance |
| rs764389373 | 12:120,593,082 | A/G | — | uncertain significance |
| rs758240571 | 12:120,593,094 | G/T | — | uncertain significance |
| rs372885273 | 12:120,593,110 | G/A | — | uncertain significance |
| rs200917600 | 12:120,593,134 | C/T | — | uncertain significance |
| rs200284000 | 12:120,593,157 | G/A | — | uncertain significance |
| rs374928766 | 12:120,593,212 | C/G | — | uncertain significance |
| rs1323599066 | 12:120,594,408 | C/T | — | uncertain significance |
| rs2503888848 | 12:120,594,766 | T/A | — | uncertain significance |
| rs112562164 | 12:120,594,809 | G/A | upstream gene variant | — |
| rs749860794 | 12:120,595,672 | G/C | — | uncertain significance |
| rs2503892135 | 12:120,595,747 | T/C | — | uncertain significance |
| rs761781373 | 12:120,595,760 | G/A | — | uncertain significance |
| rs762831193 | 12:120,595,771 | G/A | — | uncertain significance |
| rs200321706 | 12:120,595,828 | G/A | — | uncertain significance |
| rs114058958 | 12:120,596,337 | C/T | — | benign |
| rs201440874 | 12:120,597,694 | G/C | — | uncertain significance |
| rs2503898140 | 12:120,597,749 | T/G | — | uncertain significance |
| rs772455354 | 12:120,597,805 | G/A | — | uncertain significance |
| rs2503898835 | 12:120,597,986 | T/C | — | uncertain significance |
| rs111451055 | 12:120,599,284 | G/A | — | benign |
| rs200875516 | 12:120,599,373 | C/T | — | uncertain significance |
| rs748428786 | 12:120,599,374 | T/C | — | uncertain significance |
| rs376246311 | 12:120,599,748 | G/A | — | uncertain significance |
| rs759506662 | 12:120,599,760 | G/A | — | likely benign |
| rs368342798 | 12:120,599,778 | C/T | — | uncertain significance |
| rs1199670232 | 12:120,599,814 | C/A | — | uncertain significance |
| rs199599369 | 12:120,599,816 | C/T | — | uncertain significance |
| rs139177797 | 12:120,600,645 | C/T | — | benign |
| rs369744175 | 12:120,600,716 | C/T | — | uncertain significance |
| rs2503909883 | 12:120,602,142 | T/G | — | uncertain significance |
| rs2503909942 | 12:120,602,169 | C/T | — | uncertain significance |
| rs745398785 | 12:120,602,229 | T/C | — | uncertain significance |
Showing 100 of 146 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.