GCOM1

GCOM1, MYZAP-POLR2M combined locus

Summary

This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternative splicing results in multiple readthrough transcript variants. Readthrough variants may encode proteins that share sequence identity with the upstream gene product or with both the upstream and downstream gene products. Some readthrough transcript variants are also expected to be candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Oct 2013]

Known Variants46 total

rsidPosition (GRCh37)AllelesClassClinVar
rs57445747315:57,896,485C/Tuncertain significance
rs222080715:57,908,655A/C
rs93725415:57,910,164G/C
rs203558782915:57,910,282G/Cuncertain significance
rs255169585515:57,910,316A/Cuncertain significance
rs55171891315:57,913,841G/Auncertain significance
rs255169678515:57,913,869A/Guncertain significance
rs36988574915:57,913,876G/Tuncertain significance
rs14492637015:57,918,041G/Tuncertain significance
rs14861873115:57,921,912G/Auncertain significance
rs255169896015:57,921,930A/Guncertain significance
rs128862066015:57,921,933A/Guncertain significance
rs203656170915:57,924,642C/Tuncertain significance
rs14730183915:57,924,714A/Cmissense variant
rs74965807315:57,925,815A/Guncertain significance
rs18600849815:57,925,839T/Cuncertain significance
rs255170033915:57,925,922A/Cuncertain significance
rs141565367115:57,931,657G/Tuncertain significance
rs76372243515:57,931,673G/Auncertain significance
rs75669056215:57,931,678C/Tuncertain significance
rs14020208615:57,953,648A/Cuncertain significance
rs14967509815:57,953,705G/Auncertain significance
rs86880601615:57,967,172G/Auncertain significance
rs77042927515:57,967,182G/Cuncertain significance
rs255171020715:57,967,216G/Cuncertain significance
rs14650588715:57,967,220G/Auncertain significance
rs37444818915:57,967,260T/Cuncertain significance
rs77160316015:57,967,263C/Guncertain significance
rs76707631615:58,004,186C/Guncertain significance
rs143490741515:58,004,226G/Auncertain significance
rs78144066715:58,004,229G/Alikely benign
rs75316409415:58,004,237A/Glikely benign
rs75889539315:58,004,248A/Cuncertain significance
rs76017263415:58,004,256G/Auncertain significance
rs19158151515:58,004,259G/Auncertain significance
rs36842822715:58,004,314C/Guncertain significance
rs37219847815:58,004,325C/Tuncertain significance
rs14593584515:58,004,340T/Cuncertain significance
rs75200821515:58,006,748G/Alikely benign
rs74773025515:58,006,757G/Alikely benign
rs19979578715:58,006,758C/Guncertain significance
rs77413414615:58,006,791C/Tuncertain significance
rs19302317115:58,006,792G/Alikely benign
rs138590479515:58,006,822G/Auncertain significance
rs20034664015:58,006,848G/Auncertain significance
rs125253011515:58,006,866G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.