GFRAL
GDNF family receptor alpha like
Summary
Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in GDF15-GFRAL signaling pathway; positive regulation of MAPK cascade; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12110721 | 6:55,190,480 | G/A | upstream gene variant | — |
| rs532430727 | 6:55,196,626 | G/A | — | uncertain significance |
| rs201482266 | 6:55,198,604 | A/T | — | uncertain significance |
| rs764669445 | 6:55,198,708 | C/A | — | uncertain significance |
| rs140172931 | 6:55,198,727 | T/G | missense variant | — |
| rs140407984 | 6:55,204,475 | C/G | intron variant | — |
| rs79872778 | 6:55,210,520 | T/C | intron variant | — |
| rs192438822 | 6:55,210,909 | G/A | intron variant | — |
| rs936760204 | 6:55,216,057 | A/T | — | uncertain significance |
| rs150000020 | 6:55,216,233 | A/C | — | uncertain significance |
| rs867718703 | 6:55,223,729 | A/G | — | uncertain significance |
| rs148997298 | 6:55,223,750 | G/A | — | uncertain significance |
| rs1185442625 | 6:55,223,793 | C/T | — | uncertain significance |
| rs376599512 | 6:55,223,838 | C/T | — | uncertain significance |
| rs73744212 | 6:55,223,875 | A/G | — | benign |
| rs765492674 | 6:55,223,888 | T/A | — | uncertain significance |
| rs779482423 | 6:55,223,909 | C/A | — | uncertain significance |
| rs748087430 | 6:55,223,933 | T/G | — | uncertain significance |
| rs191125317 | 6:55,227,807 | A/G | intron variant | — |
| rs187914564 | 6:55,257,387 | T/C | intron variant | — |
| rs60761034 | 6:55,258,516 | C/T | intron variant | — |
| rs765641139 | 6:55,264,019 | A/G | — | uncertain significance |
| rs2481375976 | 6:55,264,031 | G/T | — | uncertain significance |
| rs758708163 | 6:55,264,070 | A/G | — | uncertain significance |
| rs145926895 | 6:55,264,227 | T/C | — | uncertain significance |
| rs780164083 | 6:55,264,235 | C/G | — | uncertain significance |
| rs1502199 | 6:55,265,021 | A/G | intron variant | — |
| rs146570795 | 6:55,266,595 | A/G | — | uncertain significance |
| rs527946821 | 6:55,266,626 | C/T | — | likely benign |
| rs149147752 | 6:55,266,629 | T/C | — | uncertain significance |
| rs776242080 | 6:55,266,637 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.