GLIPR2
GLI pathogenesis related 2
Summary
Enables protein homodimerization activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Located in Golgi membrane. Biomarker of pancreatic ductal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs747617207 | 9:36,136,837 | C/T | — | likely benign |
| rs1824841969 | 9:36,136,849 | C/A | — | likely benign |
| rs144521227 | 9:36,147,794 | T/C | — | uncertain significance |
| rs147657213 | 9:36,147,798 | A/C | — | uncertain significance |
| rs2489326383 | 9:36,147,828 | A/G | — | uncertain significance |
| rs781535657 | 9:36,147,846 | T/C | — | uncertain significance |
| rs771790962 | 9:36,147,852 | C/G | — | uncertain significance |
| rs16932994 | 9:36,147,871 | C/T | — | benign |
| rs138413630 | 9:36,147,881 | G/A | — | uncertain significance |
| rs143015896 | 9:36,148,548 | T/C | — | uncertain significance |
| rs201812895 | 9:36,148,567 | C/T | — | uncertain significance |
| rs559103985 | 9:36,159,871 | G/A | — | — |
| rs2489355813 | 9:36,162,376 | G/T | — | uncertain significance |
| rs755016981 | 9:36,162,383 | A/T | — | uncertain significance |
| rs73648727 | 9:36,162,426 | C/T | — | likely benign |
| rs1046499773 | 9:36,162,499 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.