GLO1
glyoxalase I
Summary
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2533872631 | 6:38,645,152 | C/A | — | uncertain significance |
| rs937662 | 6:38,646,369 | C/T | intron variant | — |
| rs190185384 | 6:38,649,850 | A/C | — | uncertain significance |
| rs201361403 | 6:38,649,882 | C/T | — | likely benign |
| rs1130534 | 6:38,650,588 | T/A | synonymous variant | — |
| rs4746 | 6:38,650,628 | T/G | missense variant | uncertain significance |
| rs778272653 | 6:38,652,275 | A/C | — | uncertain significance |
| rs2471999 | 6:38,652,456 | G/T | intron variant | — |
| rs10484854 | 6:38,664,594 | C/A | — | — |
| rs12209477 | 6:38,669,799 | C/T | — | — |
| rs759126965 | 6:38,670,757 | G/C | — | uncertain significance |
| rs757622327 | 6:38,670,789 | C/A | — | uncertain significance |
| rs767814917 | 6:38,670,791 | C/T | — | uncertain significance |
| rs113061497 | 6:38,670,803 | C/T | — | uncertain significance |
| rs1049346 | 6:38,670,837 | G/A | regulatory region variant | — |
| rs1781735 | 6:38,672,079 | G/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.