GMNN
geminin DNA replication inhibitor
Summary
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
Known Variants80 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs148482261 | 6:24,777,466 | A/G | — | benign |
| rs752299819 | 6:24,777,486 | T/C | — | likely benign |
| rs864309486 | 6:24,777,490 | A/T | stop gained | pathogenic |
| rs34891389 | 6:24,777,517 | A/C | — | likely benign |
| rs864309488 | 6:24,777,524 | A/G | missense variant | pathogenic |
| rs750608483 | 6:24,777,536 | G/C | — | likely benign |
| rs16889688 | 6:24,780,725 | C/T | — | benign |
| rs1923185 | 6:24,780,892 | A/C | — | benign |
| rs763963078 | 6:24,780,901 | T/G | — | uncertain significance |
| rs774279982 | 6:24,780,903 | C/T | — | conflicting classifications of pathogenicity |
| rs369051791 | 6:24,780,912 | A/G | — | uncertain significance |
| rs753908717 | 6:24,780,930 | C/G | — | uncertain significance |
| rs2307300 | 6:24,780,944 | C/A | — | benign |
| rs1260304852 | 6:24,780,980 | A/G | — | likely benign |
| rs192454776 | 6:24,780,987 | A/C | — | likely benign |
| rs2245409 | 6:24,781,025 | G/A | — | benign |
| rs9467311 | 6:24,781,239 | G/C | — | benign |
| rs150391376 | 6:24,781,711 | G/A | — | conflicting classifications of pathogenicity |
| rs2307307 | 6:24,781,719 | G/C | — | benign |
| rs1053229509 | 6:24,781,733 | A/G | — | uncertain significance |
| rs2307306 | 6:24,781,735 | C/T | — | benign |
| rs1299547560 | 6:24,781,747 | T/C | — | likely benign |
| rs2307302 | 6:24,781,753 | T/C | — | likely benign |
| rs752671362 | 6:24,781,759 | A/G | — | uncertain significance |
| rs2532435643 | 6:24,781,761 | T/G | — | likely benign |
| rs2532435779 | 6:24,781,780 | G/A | — | uncertain significance |
| rs2532435819 | 6:24,781,792 | A/G | — | uncertain significance |
| rs757821319 | 6:24,781,807 | C/A | — | uncertain significance |
| rs781516962 | 6:24,781,808 | T/C | — | uncertain significance |
| rs138954355 | 6:24,781,809 | T/C | — | likely benign |
| rs754589141 | 6:24,781,811 | G/C | — | uncertain significance |
| rs1004696853 | 6:24,781,820 | C/G | — | uncertain significance |
| rs2113578950 | 6:24,781,822 | C/A | — | uncertain significance |
| rs2532436125 | 6:24,781,840 | A/T | — | uncertain significance |
| rs577488599 | 6:24,781,841 | T/C | — | likely benign |
| rs2532436139 | 6:24,781,842 | G/T | — | uncertain significance |
| rs201417437 | 6:24,781,861 | T/A | — | likely benign |
| rs1780224457 | 6:24,781,864 | A/G | — | likely benign |
| rs9467316 | 6:24,784,052 | C/T | — | benign |
| rs764223940 | 6:24,784,297 | T/A | — | likely benign |
| rs774346905 | 6:24,784,304 | T/C | — | likely benign |
| rs2113583678 | 6:24,784,316 | A/G | — | uncertain significance |
| rs768047063 | 6:24,784,322 | A/G | — | likely benign |
| rs377373371 | 6:24,784,327 | C/G | — | uncertain significance |
| rs2532441963 | 6:24,784,332 | T/C | — | uncertain significance |
| rs758033028 | 6:24,784,356 | C/T | — | uncertain significance |
| rs746531592 | 6:24,784,363 | A/G | — | likely benign |
| rs757212388 | 6:24,784,366 | C/T | — | uncertain significance |
| rs145822661 | 6:24,784,367 | G/A | — | likely benign |
| rs769709120 | 6:24,784,370 | G/A | — | likely benign |
| rs202155543 | 6:24,784,393 | A/G | — | uncertain significance |
| rs2307305 | 6:24,784,404 | A/G | — | benign |
| rs2307308 | 6:24,784,436 | T/C | — | benign |
| rs2532443503 | 6:24,784,657 | A/G | — | likely benign |
| rs2307304 | 6:24,784,661 | A/T | — | benign |
| rs1581431798 | 6:24,784,680 | A/G | — | likely benign |
| rs2532443608 | 6:24,784,690 | C/T | — | uncertain significance |
| rs2113584398 | 6:24,784,695 | G/A | — | likely benign |
| rs771371885 | 6:24,784,711 | C/T | — | conflicting classifications of pathogenicity |
| rs201577150 | 6:24,784,712 | G/A | — | uncertain significance |
| rs199710640 | 6:24,784,720 | A/G | — | conflicting classifications of pathogenicity |
| rs751254224 | 6:24,784,725 | G/A | — | likely benign |
| rs1780299041 | 6:24,784,740 | A/G | — | likely benign |
| rs201007411 | 6:24,784,777 | A/G | — | conflicting classifications of pathogenicity |
| rs58898420 | 6:24,784,891 | G/A | — | benign |
| rs10946726 | 6:24,785,039 | T/C | — | benign |
| rs2145752 | 6:24,785,582 | G/C | — | benign |
| rs2295735 | 6:24,785,688 | A/G | — | benign |
| rs1166561856 | 6:24,785,855 | T/G | — | uncertain significance |
| rs201229321 | 6:24,785,863 | A/G | — | uncertain significance |
| rs2532447411 | 6:24,785,887 | G/A | — | uncertain significance |
| rs991501358 | 6:24,785,889 | T/A | — | uncertain significance |
| rs2532447424 | 6:24,785,892 | T/G | — | uncertain significance |
| rs1196862808 | 6:24,785,921 | A/G | — | uncertain significance |
| rs1236825175 | 6:24,785,936 | C/G | — | uncertain significance |
| rs373551106 | 6:24,785,976 | G/A | — | likely benign |
| rs2307303 | 6:24,786,005 | C/T | — | benign |
| rs558038900 | 6:24,786,019 | T/C | — | uncertain significance |
| rs2532448003 | 6:24,786,023 | T/C | — | uncertain significance |
| rs2307309 | 6:24,786,271 | C/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.