GPX5
glutathione peroxidase 5
Summary
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs28382587 | 6:28,492,579 | G/A | upstream gene variant | — |
| rs143719221 | 6:28,493,808 | G/C | — | uncertain significance |
| rs386352313 | 6:28,493,818 | C/T | — | uncertain significance |
| rs35901019 | 6:28,494,225 | G/A | intron variant | — |
| rs113787419 | 6:28,496,990 | T/A | upstream gene variant | — |
| rs554303695 | 6:28,497,234 | T/G | — | uncertain significance |
| rs543973750 | 6:28,497,348 | G/A | — | uncertain significance |
| rs2481015384 | 6:28,497,357 | T/C | — | uncertain significance |
| rs1271480213 | 6:28,497,360 | G/T | — | uncertain significance |
| rs752846831 | 6:28,497,376 | A/C | — | uncertain significance |
| rs2481018503 | 6:28,499,587 | T/G | — | uncertain significance |
| rs532584620 | 6:28,499,588 | A/G | — | uncertain significance |
| rs371340466 | 6:28,499,657 | T/A | — | uncertain significance |
| rs1213371172 | 6:28,500,105 | C/T | — | uncertain significance |
| rs1403941062 | 6:28,500,183 | T/C | — | uncertain significance |
| rs1278372071 | 6:28,501,744 | T/C | — | uncertain significance |
| rs2481021634 | 6:28,501,759 | G/A | — | uncertain significance |
| rs780349667 | 6:28,501,879 | C/T | — | uncertain significance |
| rs531172601 | 6:28,501,916 | C/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.