GSK3A
glycogen synthase kinase 3 alpha
Summary
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2513497318 | 19:42,735,020 | C/A | — | uncertain significance |
| rs770282435 | 19:42,736,671 | G/T | — | uncertain significance |
| rs146606692 | 19:42,736,775 | G/A | — | benign |
| rs553543282 | 19:42,736,949 | C/A | — | — |
| rs2513500485 | 19:42,737,451 | A/C | — | uncertain significance |
| rs2513500564 | 19:42,737,503 | G/C | — | uncertain significance |
| rs2513501968 | 19:42,738,788 | A/G | — | uncertain significance |
| rs2146938212 | 19:42,741,053 | T/C | — | uncertain significance |
| rs1209337771 | 19:42,744,198 | T/C | — | uncertain significance |
| rs774878085 | 19:42,744,241 | G/A | — | uncertain significance |
| rs765917283 | 19:42,746,355 | G/A | — | uncertain significance |
| rs2513508590 | 19:42,746,387 | G/C | — | uncertain significance |
| rs2146941249 | 19:42,746,439 | A/C | — | uncertain significance |
| rs779095296 | 19:42,746,451 | A/C | — | uncertain significance |
| rs2513508724 | 19:42,746,460 | A/C | — | uncertain significance |
| rs1131690798 | 19:42,746,472 | C/G | — | uncertain significance |
| rs2036298371 | 19:42,746,476 | C/T | — | uncertain significance |
| rs1256218535 | 19:42,746,494 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.